Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and function
| Project/Area Number |
22592047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SEKINE Keisuke 横浜市立大学, 医学部, 助教 (00323569)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞分化 / 組織形成 / 発生 / 分化制御 / 骨代謝学 / 免疫 / 感染 / 炎症 / 破骨細胞分化 / 破骨細胞前駆細胞株4B12細胞 / 内因性Wntシグナル / β-catenin / GSK-3β阻害 / TCF/LEF / DC-STAMP / Wnt / canonical経路 / Tm7sf4 / Sclerostin / 破細胞分化 / 破骨細胞上駆細胞株4B12細胞 / sFrp2 / sclerostin / β-カテニン / siRNA |
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| Research Abstract |
Periodontitis is a chronic inflammatory disease caused by infection of periodontopathic bacteriae, which induces alveolarbone resorption. The alveolar bone resorption is characterized by an increased osteoclastic bone resorption that exceeds the bone formation by osteoblasts. This study clarified that Wnt signaling, which is a critical regulator controlling cell proliferation, movement, differentiation, polarity, and morphogenesis, plays a role in the enhancement both the fusion process during osteoclast differentiation and the expression of osteoclastic bone resorption-related genes.
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Report
(4 results)
Research Products
(4 results)
