| Project/Area Number |
22592049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Showa University |
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Principal Investigator |
KOHNO Yohko 昭和大学, 歯学部, 准教授 (40195681)
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| Co-Investigator(Kenkyū-buntansha) |
MURAMATSU Takashi 東京歯科大学, 歯学部, 講師 (00276982)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 唾液腺腫瘍 / 多形腺腫 / 多形腺腫由来癌 / 形質転換 / DNA損傷遺伝子 |
|---|
| Research Abstract |
In a tumor of salivary gland, a pleomorphic adenoma is a benign tumor with the highest frequency, and when it passes at a long period of time, carrying out malignant alteration is known. The cause which a benign tumor transforms into a malignant tumor was searched using the atypical pleomorphic adenoma and carcinoma ex pleomorphic-adenoma to which the benign part and the malignant part are intermingled in the same tumor. The part as which the malignant tumor was regarded showed p63 immunohistochemical staining and EMA immunohistochemical staining were positive, what both the myoepithelial cell and the ductal-epithelium cell transformed became clear, and it checked that the protein which participates in DNA repair protein or cell cycle related protein were over expressed by those parts.
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