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Histochemical and neurochemical studies on the biological basis of orofacial neuropathic pain

Research Project

Project/Area Number 22592051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

SAIGUSA Tadashi  日本大学, 歯学部, 専任講師 (50277456)

Co-Investigator(Kenkyū-buntansha) TSUBOI Yoshiyuki  日本大学, 歯学部, 専任講師 (50246906)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経因性疼痛 / 難治性疼痛 / 三叉神経脊髄路核尾側亜核 / 側坐核 / アドレナリン受容体 / 三叉神経 / 延髄 / アストログリア / ドパミン / GABA / allylglycine / 眼窩下神経 / PKCγ / 線条体 / Ca^<2+> / SKF38393
Research Abstract

Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (22 results) Remarks (4 results)

  • [Journal Article] Cools A R. The α1-, but not α2-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux offreely moving rats.2012

    • Author(s)
      Saigusa T, Aono Y, Uchida T, Takada K, Verheij MMM, Koshikawa N
    • Journal Title

      Eur J Pharmacol

      Volume: 688 Pages: 35-41

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cools AR. In vivo neurochemical evidence that newly synthesised GABA activates GABAB, but not GABAA, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats.2012

    • Author(s)
      Saigusa T, Aono Y, Sekino R, Uchida T, Takada K, Oi Y, Koshikawa N
    • Journal Title

      Neuropharmacology

      Volume: 62 Pages: 907-913

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The α1-, but not α2-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats2012

    • Author(s)
      Tadashi Saigusa
    • Journal Title

      European Journal of Pharmacology

      Volume: 688 Pages: 35-41

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo neurochemical evidence that newly synthesised GABA activates GABA_B, but not GABA_A, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats2012

    • Author(s)
      Tadashi Saigusa, et al
    • Journal Title

      Neuropharmacology

      Volume: 62 Issue: 2 Pages: 907-913

    • DOI

      10.1016/j.neuropharm.2011.09.021

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain.2011

    • Author(s)
      Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, Matsuura S, Shibuta K, Yasuda M, Shimizu N, Iwata K.
    • Journal Title

      J Dent Res.

      Volume: 90 Pages: 777-781

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis.2011

    • Author(s)
      Tsuboi Y, Iwata K, Dostrovsky JO, Chiang CY, Sessle BJ, Hu JW.
    • Journal Title

      Eur J Neurosci

      Volume: 34 Pages: 292-302

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis2011

    • Author(s)
      Yoshiyuki Tsuboi, et al
    • Journal Title

      European Journal of Neuroscience

      Volume: 34 Issue: 2 Pages: 292-302

    • DOI

      10.1111/j.1460-9568.2011.07747.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PKCγ in Vc and C1/C2 is involved in trigeminal neuropathic pain.2011

    • Author(s)
      Akira Nakajima
    • Journal Title

      Journal of Dental Research

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cools AR. Dopamine D1-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393.2010

    • Author(s)
      Sekino R, Saigusa T, Aono Y, Uchida T, Takada K, Oi Y, Koshikawa N
    • Journal Title

      Eur J Pharmacol

      Volume: 648 Pages: 80-86

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D1-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF383932010

    • Author(s)
      Reiko Sekino
    • Journal Title

      European Journal of Pharmacology

      Volume: 648 Pages: 80-86

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラットの側坐核のドパミン放出抑制におけるα1受容体サブタイプの関与.2013

    • Author(s)
      三枝禎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場,福岡県福岡市
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Alpha-1?, but not alpha-2-adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats.2012

    • Author(s)
      Saigusa T.
    • Organizer
      28th The International College of Neuropsychopharmacology (CINP)
    • Place of Presentation
      Stockholmsmassan, Stockholm, Sweden
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Simultaneous, but not separate activation of beta-1? and beta-2?adrenoceptors in the nucleus accumbens increases accumbal dopamine efflux in freely moving rats.2012

    • Author(s)
      Saigusa T.
    • Organizer
      28th The International College of Neuropsychopharmacology (CINP)
    • Place of Presentation
      Stockholmsmassan, Stockholm, Sweden
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの側坐核のノルアドレナリンおよびドパミン放出のα1受容体を介した抑制性制御機構.2012

    • Author(s)
      三枝禎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館,京都府京都市
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 選択的β受容体サブタイプ作動薬がラットの側坐核ノルアドレナリンおよびドパミン放出へ及ぼす効果2012

    • Author(s)
      三枝禎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館,京都府京都市
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Mecp2ヘテロ接合雌マウスの視床下部外側野のノルアドレナリン神経活動の特徴2012

    • Author(s)
      滝口旗一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 選択的β受容体サブタイプ作動薬がラットの側坐核ノルアドレナリンおよびドパミン放出へ及ぼす効果2012

    • Author(s)
      青野悠里
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラットの側坐核のノルアドレナリンおよびドパミン放出のα_1受容体を介した抑制性制御機構2012

    • Author(s)
      三枝禎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mecp2ヘテロ接合雌マウスの視床下部外側野のノルアドレナリン神経活動の特徴.2012

    • Author(s)
      三枝禎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館,京都府京都市
    • Related Report
      2012 Final Research Report
  • [Presentation] CholecystokininまたはreboxetineがMecp2ヘテロ接合雌マウスの視床下部外側野の細胞外ノルアドレナリン量に及ぼす効果.2011

    • Author(s)
      三枝禎
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      京王プラザホテル,東京都新宿区
    • Year and Date
      2011-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Mecp2ヘテロ接合雌マウスの視床下部外側野の細胞外ノルアドレナリン量へcholecystokininおよびreboxetineが及ぼす効果.2011

    • Author(s)
      三枝禎
    • Organizer
      第125回日本薬理学会関東部会
    • Place of Presentation
      日本大学薬学部8号館,千葉県船橋市
    • Year and Date
      2011-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Mecp2ヘテロ接合雌マウスの視床下部外側野の細胞外ノルアドレナリン量へcholecystokininおよびreboxetineが及ぼす効果2011

    • Author(s)
      滝口旗一
    • Organizer
      第125回日本薬理学会関東部会
    • Place of Presentation
      日本大学薬学部(千葉県)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] The alpha-1 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats.2011

    • Author(s)
      Saigusa T.
    • Organizer
      2nd Congress of Asian College ofNeuropsychopharmacology Jointly with 2011Annual Meeting of Korean College of Neuropsychopharmacology, Grand Hilton Seoul Hotel
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの側坐核ノルアドレナリンおよびドパミン遊離制御におけるα1受容体の役割2011

    • Author(s)
      三枝禎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2011-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの側坐核ノルアドレナリンおよびドパミン遊離制御におけるα_1受容体の役割2011

    • Author(s)
      関野麗子
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] CholecystokininまたはreboxetineがMecp2ヘテロ接合雌マウスの視床下部外側野の細胞外ノルアドレナリン量に及ぼす効果2011

    • Author(s)
      滝口旗一
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The alpha-1 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats2011

    • Author(s)
      Tadashi Saigusa
    • Organizer
      2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of Korean College of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット線条体背側部へのSKF38393局所投与で誘発される細胞外DA量の増加におけるCa2+の関与.2010

    • Author(s)
      三枝禎
    • Organizer
      第123回日本薬理学会関東部会
    • Place of Presentation
      自治医科大学地域医療情報研修センター,栃木県下野
    • Year and Date
      2010-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット線条体背側部へのSKF38393局所投与で誘発される細胞外ドパミン量の増加におけるCa^<2+>の関与2010

    • Author(s)
      関野麗子
    • Organizer
      第123回日本薬理学会関東部会
    • Place of Presentation
      自治医科大学(栃木県)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットのallylglycine誘発側坐核ドパミン遊離亢進におけるGABAB受容体の関与2010

    • Author(s)
      三枝禎
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台国際センター,宮城県仙台市
    • Year and Date
      2010-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットのallylglycine誘発側坐核ドパミン遊離亢進におけるGABA_B受容体の関与2010

    • Author(s)
      関野麗子
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alpha-1, but not alpha-2 adrenoceptor in the nucleus accumbens exerts an inhibitory control upon the accumbal noradrenaline and dopamine efflux in freely moving rats.

    • Author(s)
      Tadashi Saigusa
    • Organizer
      28th The International College of Neuropsychopharmacology (CINP)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究内容の平易な紹介 三枝禎

    • URL

      http://www.bitway.ne.jp/ejournal/biglobe/2425100899.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 坪井美行

    • URL

      https://sites.google.com/site/nusdphysiology/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.nihon-u.ac.jp/community_and_service/publication/newsletter/nu_excellence/9-04.pdf

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nihon-u.ac.jp/community_and_service/publication/newsletter/nu_excellence/9-04.pdf

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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