Histochemical and neurochemical studies on the biological basis of orofacial neuropathic pain
Project/Area Number |
22592051
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Nihon University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TSUBOI Yoshiyuki 日本大学, 歯学部, 専任講師 (50246906)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 神経因性疼痛 / 難治性疼痛 / 三叉神経脊髄路核尾側亜核 / 側坐核 / アドレナリン受容体 / 三叉神経 / 延髄 / アストログリア / ドパミン / GABA / allylglycine / 眼窩下神経 / PKCγ / 線条体 / Ca^<2+> / SKF38393 |
Research Abstract |
Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.
|
Report
(4 results)
Research Products
(36 results)
-
-
-
-
-
[Journal Article] PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain.2011
Author(s)
Nakajima A, Tsuboi Y, Suzuki I, Honda K, Shinoda M, Kondo M, Matsuura S, Shibuta K, Yasuda M, Shimizu N, Iwata K.
-
Journal Title
J Dent Res.
Volume: 90
Pages: 777-781
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-