| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.
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