Spatiotemporal analysis of a TPO signal control mechanism and examination of clinical application in pulp chamber high order blood vessel construction
| Project/Area Number |
22592052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Kazuo 国立感染症研究所, 免疫部, 主任研究員 (90169011)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔解剖学（含組織学・発生学） / 歯髄 / 血管 / トロンボポエチン / 歯胚 / TPO / vegfr / 歯 胚 / 歯 髄 / c-Mpl |
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| Research Abstract |
This research will clarify the molecular mechanism of interactions between TPO/MPL signals, blood vessel formation related gene, to consider the possibility of the clinical application of dental pulp regeneration purposes as research. using in situ hybridization, temporal analysis of TPO/MPL signal-related gene expression of results the tooth germ full time showed species-specific TPO/MPL signal-related gene expression. On the other hand, by using in situ hybridization analysis of VEGFR-2 genes over time of expression situation went, the tooth germ region observed period-specific VEGFR-2 gene expression. Expected results of this research will contribute pulp vascular development control mechanism.
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Report
(5 results)
Research Products
(20 results)
