| Project/Area Number |
22592053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIFUJI Akira 鶴見大学, 歯学部, 教授 (00240747)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯根膜 / 組織幹細胞 / アネキシン a5 / アネキシンA5（Anxa5） / 腱 / アポトーシス / アネキシンA5(Anxa5) / β-galactosidase |
|---|
| Research Abstract |
Localization and function of Annexin a5 (Anxa5) expressing cells in the periodontal tissues were histologically analyzed. At 1 week after birth, Anxa5 was expressed at the area for tooth root formation. At 4 weeks after birth, Anxa5 was expressed in apex and cervical areas of tooth roots, cementblasts, periosteum, and perivascular areas. In the process of periodontal regeneration after tooth replantation at 6 weeks after birth, Anxa5 positive cells were markedly increased in the periodontal tissues at 3 days after replantation. At 8 weeks after birth, Anxa5 deficient mice showed less cement formation at the root apexes and wider periodontal ligament than those of wild mice. On the other hand, adult long bones of Anxa5 deficient mice showed larger bone formation at the insertionsites of tendon and ligament than those of wild mice. These results suggest that Anxa5 is involved in the process of development, remodeling and regeneration of hard tissues including surrounding soft tiss
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