| Project/Area Number |
22592054
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Asahi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOYAMA Noriko 朝日大学, 歯学部, 准教授 (60367563)
HAYASHI Toru 朝日大学, 歯学部, 助教 (10454266)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | 上皮間葉相互作用 / 分枝形態形成 / EGF / HGF / 器官培養 / 顎下腺原基 / 唾液腺 / 顎下腺 / 細胞成長因子 / 肝細胞成長因子 / 上皮細胞成長因子 / 受容体 / c-Met / ERK1/2 |
|---|
| Research Abstract |
HGFisknowntoregulatebranchingmorphogenesisoffetalmousesubmandibulargland(SMG).However,themechanismsofregulationofbranchingmorphogenesisarelargelyunknown.HGFweaklystimulatesbranchingmorphogenesisandinducedmorphologicalchangesofsurfaceofbudsofSMGrudiments.Byusingmesenchyme-freeepithelialculturesystem,wecouldobservethatHGFstimulatecleftformationofSMGepithelium.HGFalsoinducedEGFreceptor(ErbB1)phosphorylationbytreatmentofculturedSMGrudimentswithHGF.TheseresultsimplythatEGF/EGFreceptorsystemisresponsible,atleastinpart,forthestimulatoryeffectofHGFonbranchingmorphogenesisofculturedSMGrudimentsandcleftformationofSMGepithelium
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