Identification of the salivary gland stem cells and elucidation of gene in the stem cells to differentiate into functional acinar cells

• Project/Area Number: 22592056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: The Nippon Dental University College at Tokyo
• Principal Investigator: IKEDA Rie 日本歯科大学東京短期大学, 歯科衛生学科, 教授 (50168150)
• Co-Investigator(Renkei-kenkyūsha): KIKUCHI Kenichiro 日本歯科大学, 生命歯学部, 教授 (80267260)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 唾液腺 / 幹細胞 / 腺房細胞 / 交感神経 / 組織・細胞 / 分化遺伝子

Research Abstract

During regeneration after ductal obstruction of Stensen-s duct, manystem cells were observed in the duct-like structures in the rat parotidgland. Regeneration of the parotid gland occurs rapidly through anappearance of stem cells. Temporarily increase in sympathetic nerves wasrecognized around the duct-like structures. These results suggest that thesympathetic nerves play an important role in regeneration of rat parotidglands.

Research Products

• [Journal Article] Morphological and Histochemical Changes in the Parenchyma of the Rat Parotid and Sublingual Glands with Growth and Aging (2011)
  • Author(s): Rie Ikeda
  • Journal Title: Journal of Oral Biosciences Volume: Vol.53、No.4 Pages: 289-297
  • NAID: 10030175384
  • Peer Reviewed
• [Journal Article] Immunohistochemical Syudy of the Lymphatic Vessels in Major Salivary Glands of the Rat (2011)
  • Author(s): Shigeo Aiyama、Kenichiro Kikuchi、KiyomiTakada 、Rie Ikeda 、Sumie Sato 、JunyaKuroki
  • Journal Title: Okajimas Folia Anatomica Japonica Volume: Vol.87、No.4 Pages: 177-180
  • Peer Reviewed
• [Journal Article] Morphological and Histochemical Changes in the Parenchyma of the Rat Parotid and Sublingual Glands with Growth and Aging (2011)
  • Author(s): Rie Ikeda
  • Journal Title: J.Oral Biosci. Volume: 53 Pages: 289-297
  • NAID: 10030175384
  • Peer Reviewed
• [Journal Article] Immunohistochemical Study of the Lymphatic Vessels in Major Salivary Glands of the Rat (2011)
  • Author(s): Shigeo Aiyama
  • Journal Title: Okajimas Folia Anat.Jpn. Volume: 87 Pages: 177-180
  • Peer Reviewed
• [Presentation] Distribution of Autonomic Nerves in Rat Parotid Gland during Regeneration (2013)
  • Author(s): Rie Ikeda
  • Organizer: International Association for Dental Research
  • Place of Presentation: シアトル、アメリカ
  • Year and Date: 2013-03-22
• [Presentation] Distribution of Autonomic Nerves in Rat Parotid Gland during Regeneration (2013)
  • Author(s): Rie Ikeda
  • Organizer: International Association for Dental Research
  • Place of Presentation: Washington State Convention Center ( アメリカ ・ シアトル )
• [Presentation] Immunohistochemical Study of Lymphatic Vessel Development of Early Postnatal Rat Salivary Gland (2012)
  • Author(s): Kenichiro Kikuchi
  • Organizer: 2012 Sino-Japan Dental Conference
  • Place of Presentation: 成都、中国
  • Year and Date: 2012-04-27
• [Presentation] Immunohistochemical Study of Lymphatic Vessel Development of Early Postnatal Rat Salivary Gland (2012)
  • Author(s): Kenichiro Kikuchi
  • Organizer: 2012 Sino-Japan Dental Conference
  • Place of Presentation: 四川大学華西口腔 医学院 ( 中国 ・ 成都 )
• [Presentation] 発育と加齢に伴うラット唾液腺分泌部実質細胞の形態および性状変化 (2010)
  • Author(s): 池田利恵
  • Organizer: 第52回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-20
• [Presentation] 発育と加齢に伴うラット唾液腺分泌部実質細胞の形態および性状変化 (2010)
  • Author(s): 池田利恵
  • Organizer: 第52回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: タワーホール船堀(東京都)(招待講演)
  • Year and Date: 2010-09-20