Identification of emesis-inducing medullary neurons and anslysis of their functions.
| Project/Area Number |
22592057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Yoshiyuki 北海道大学, 大学院・歯学研究科, 助教 (40344519)
MAEZAWA Hitoshi 北海道大学, 大学院・歯学研究科, 教授 (80567727)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔生理学 / 最後野 / 脳スライス / 悪心 / 嘔吐 / 味覚嫌悪学習 / パッチクランプ / ラット / 化学受容性嘔吐誘発域 |
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| Research Abstract |
We investigated how neurons in the area postrema known as a chemoreceptor trigger zone are related to the induction of nausea and/or emesis and to the control of food intake. We found that the neurons expressing H channels are closely related to the induction of nausea but they do not respond to amylin that is known as a satiety peptide. Responses to amylin were found only in the neurons not expressing H channels. We concluded that these date suggested the presence of functional differentiation between the neurons expressing H channels and the neurons not expressing H channels.
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Report
(4 results)
Research Products
(41 results)
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[Presentation] ZD7288の味覚嫌悪学習への影響2010
Author(s)
新保圭亮,平井喜幸,前澤仁志,石尾知亮,福田武志,戸塚靖則,舩橋誠
Organizer
第52回歯科基礎医学会,Journal of OralBiosciences,52(supple)
Place of Presentation
タワーホール船堀(東京)
Year and Date
2010-09-21
Related Report
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