| Project/Area Number |
22592059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHINODA Hisashi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (80014025)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Kaoru 東北大学, 大学院・歯学研究科, 教授 (70202851)
MURAKAMI Shinobu 東北大学, 大学院・歯学研究科, 大学院非常 勤講師 (40436093)
CHIBA Mirei 東北大学, 大学院・歯学研究科, 講師 (10236820)
SUZUKI Keiko 昭和大学, 歯学部, 講師 (50119187)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ビスホスホネート / 歯周病 / 骨形成 / 骨吸収 / NF-κB / NF-KB / NF-kB |
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| Research Abstract |
The current study was carried out to investigate by what mechanism a novel bisphosphonate, [4-(methylthio) phenylthio] methanebisphosphonate (MPMBP), can promote bone formation, and whether this compound can be effective on the periodontitis. Our results show that MPMBP promotes the expression of mRNA that relates osteogenesis, and that this compound was effective on the experimental periodontitis in rats and dogs. MPMBP may be used not only for the treatment of periodontitis, but also for various conditions that require the regeneration of bone tissues.
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