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Elucidation of molecular mechanisms of osteoclastogenesis by iron

Research Project

Project/Area Number 22592069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNagasaki University

Principal Investigator

SAKAI Eiko  長崎大学, 大学院・医歯薬学総合研究科, 助教 (10176612)

Co-Investigator(Kenkyū-buntansha) TSUKUBA Takayuki  長崎大学, 大学院・医歯薬学総合研究科, 教授 (30264055)
OKAMOTO Kuniaki  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10311846)
NISHISHITA Kazuhisa  長崎大学, 大学院・医歯薬学総合研究科, 助教 (20237697)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords骨代謝 / 破骨細胞 / 酸化ストレス / ポリフェノール / ヘムオキシゲナーゼ / 鉄代謝 / NFATc1 / ヘムオキシゲナーゼ1 / HMGB1 / カスパーゼ3 / ストレス / 発生・分化 / 歯学
Research Abstract

We reported that RANKL-induced suppression of heme oxygenase-1 (HO-1), a heme-degrading enzyme, promoted caspase3 activation and HMGB1 release during osteoclastogenesis. Induction of HO-1 by tBHQ or polyphenol such as kahweol and fisetin inhibited osteoclastogenesis respectively. Since transcriptional induction of HO-1 is up-regulated by Nrf2, we studied the effect of Nrf2 on osteoclastogenesis. Studies with Nrf2 KO mice bone marrow macrophages showed enhanced formation of osteoclasts compared with wild type mice bone marrow macrophages.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2013 2012 2011 2010

All Journal Article (19 results) (of which Peer Reviewed: 17 results,  Open Access: 1 results) Presentation (44 results) Book (1 results)

  • [Journal Article] Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase II Antioxidant Enzymes2013

    • Author(s)
      Y, Sakamoto H, Fumimoto R, Fukuma Y, Nishishita K, Okamoto K, and TsukubaT.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 121 Issue: 4 Pages: 288-298

    • DOI

      10.1254/jphs.12243FP

    • NAID

      10031171138

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural and phylogenetic comparison of napsin genes: The duplication, loss of function and human-specific pseudogenization of napsin B2013

    • Author(s)
      Nishishita K, Sakai E, Okamoto K, Tsukuba T.
    • Journal Title

      Gene

      Volume: 517(2) Pages: 147-57

    • NAID

      120006986226

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression2013

    • Author(s)
      Yamaguchi Y, Sakai E, Sakamoto H, Fumimoto R, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T.
    • Journal Title

      J Appl Toxicol

      Volume: (in press) Issue: 1 Pages: 0-0

    • DOI

      10.1002/jat.2827

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenese-1 and NFATc12012

    • Author(s)
      Sakamoto H, Sakai E, Fumimoto R, Yamaguchi Y, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T
    • Journal Title

      Toxicol. in Vitro

      Volume: 26 Pages: 817-822

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation2012

    • Author(s)
      Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T
    • Journal Title

      J Pharmacol Sci

      Volume: 118(4) Pages: 479-486

    • NAID

      10030572053

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice2012

    • Author(s)
      Narahara S, Matsushima H, Sakai E, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T
    • Journal Title

      Cell Tissue Res

      Volume: 348 Pages: 81-94

    • NAID

      120006985410

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene2012

    • Author(s)
      Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K
    • Journal Title

      J Biochem

      Volume: 151 Pages: 263-272

    • NAID

      10031166065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis2012

    • Author(s)
      Sakai E, Shimada-Sugawara M, Nishishita K, Fukuma Y, Naito M, Okamoto K, Nakayama K, Tsukuba T
    • Journal Title

      J Cell Biochem

      Volume: 113 Pages: 486-498

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin E is critical for proper trafficking of cell surface proteins2012

    • Author(s)
      Tsukuba T., Okamoto K., and Yamamoto K.
    • Journal Title

      J Oral Biosci

      Volume: 54 Pages: 48-53

    • Related Report
      2012 Final Research Report
  • [Journal Article] Emerging roles of cathepsin E in host defense mechanisms2012

    • Author(s)
      Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1824 Pages: 105-112

    • NAID

      120005324431

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation.2012

    • Author(s)
      Fumimoto Reiko
    • Journal Title

      Journal of Pharmacological Science

      Volume: 118 Pages: 479-486

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1.2012

    • Author(s)
      Sakamoto Hiroshi
    • Journal Title

      Toxicology in Vitro

      Volume: 26 Issue: 6 Pages: 817-822

    • DOI

      10.1016/j.tiv.2012.05.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis2012

    • Author(s)
      Sakai E, 他7名
    • Journal Title

      J.Cell.Biochem.

      Volume: 113 Issue: 2 Pages: 486-498

    • DOI

      10.1002/jcb.23372

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice2012

    • Author(s)
      Narahara S, 他6名
    • Journal Title

      Cell.Tissue Res.

      Volume: 348(1) Issue: 1 Pages: 81-94

    • DOI

      10.1007/s00441-012-1325-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation2012

    • Author(s)
      Fumimoto Reiko
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 118 Issue: 4 Pages: 479-486

    • DOI

      10.1254/jphs.11212FP

    • NAID

      10030572053

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering bone formation from human dental pulp- and periodontal ligament-derived cells2011

    • Author(s)
      Ikeda H, Sumita Y, Ikeda M, Ikeda H, Okumura T, Sakai E, Nishimura M, Asahina I
    • Journal Title

      nn Biomed Eng

      Volume: 39(1) Pages: 26-34

    • NAID

      120006984446

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis2011

    • Author(s)
      Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K
    • Journal Title

      Microbiol Immunol

      Volume: 55(3) Pages: 141-153

    • NAID

      10031121453

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of cathepsin E in terminal differentiation of keratinocytes. Biol2011

    • Author(s)
      Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K
    • Journal Title

      Chem.

      Volume: 392(6) Pages: 571-585

    • Related Report
      2012 Final Research Report
  • [Journal Article] The receptor potential of frog taste cells in response to cold and warm stimuli2010

    • Author(s)
      Sato T, Nishishita K, Okada Y, Toda K
    • Journal Title

      Chem Senses

      Volume: 35(6) Pages: 491-499

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Cafestol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation2013

    • Author(s)
      Fukuma Yutaka, Sakai Eiko, Sugawara Megumi, Erika Yoneshima, Nishishita Kazuhisa, Okamoto Kuniaki, and Tsukuba Takayuki
    • Organizer
      第86回日本薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Up-regulation mechanisms of endosomal/lysosomal proteins during osteoblastdifferentiation2013

    • Author(s)
      Erika Yoneshima, Kuniaki Okamoto, Eiko Sakai, Noriaki Yoshida, and Takayuki Tsukuba
    • Organizer
      第86回日本薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] カフェストールはNFATc1の発現とErkのリン酸化を阻害し破骨細胞分化を抑制する2013

    • Author(s)
      福間裕
    • Organizer
      第86回日本薬理学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] RANKL依存的HO-1発現抑制はHMGB1の遊離と破骨細胞分化に必要である2012

    • Author(s)
      坂井詠子
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] フィセチンはNFATc1の発現とErkのリン酸化を抑制し破骨細胞分化を阻害する2012

    • Author(s)
      菅原めぐみ
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] p53 はカテプシンE遺伝子の発現を制御する2012

    • Author(s)
      岡元邦彰,岩田淳一,坂井詠子,西下一久,山本健二,筑波隆幸
    • Organizer
      第85回日本生化学会大会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] フィセチンはRANKLを介したROSの産生とNFATc1の発現を抑制することで破骨細胞分化を阻害する2012

    • Author(s)
      坂井詠子,菅原めぐみ,福間 裕,西下一久,岩竹真弓,米嶋枝里香,岡元邦彰,筑波隆幸
    • Organizer
      第85回日本生化学会大会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Cafestolの破骨細胞形成と骨吸収活性への影響2012

    • Author(s)
      福間 裕,坂井詠子,菅原めぐみ,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Fisetin prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation2012

    • Author(s)
      Megumi Sugawara, Eiko Sakai, Kazuhisa Nishishita, Yutaka Fukuma, Kuniaki Okamoto, Noriaki Yoshida and Takayuki Tsukuba
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Suppression of RANKL-dependent hemeactivator of NF κ B ligand dependentsuppression is required for high mobility group box 1 and osteoclastogenesis2012

    • Author(s)
      Eiko Sakai, Megumi Sugawara, Kazuhisa Nishishita, Yutaka Fukuma, Kuniaki Okamoto and Takayuki Tsukuba
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Accumulation of NADPH oxidase (NOX2) and increased oxidative stress in cathepsin E-deficient macrophages2012

    • Author(s)
      Takayuki Tsukuba, Tomoko Kadowaki, Kuniaki Okamoto, Kenji Yamamoto
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of two transcripts and in vivo promoter analysis for cathepsin E2012

    • Author(s)
      Kuniaki Okamoto, Yoshiko Okamoto, Eiko Sakai, Kazuhisa Nishishita, KenjiYamamoto, and Takayuki Tsukuba
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Cathepsin E-induced growth arrest and apoptosis of cancer cells and the related signaling2012

    • Author(s)
      Kenji Yamamoto, Tomoyo Kawakubo, Atsushi Yasukouchi, and Takayuki Tsukuba
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      (シンポジウム) ,京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Fisetin の破骨細胞形成と骨吸収活性への影響2012

    • Author(s)
      坂井詠子,菅原めぐみ,福間 裕,西下一久,岡元邦彰,筑波隆幸
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2012 Final Research Report
  • [Presentation] Fisetinの破骨細胞形成と骨吸収活性への影響2012

    • Author(s)
      坂井詠子
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] フィセチンによる破骨細胞分化抑制作用2011

    • Author(s)
      菅原めぐみ
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKR博多(福岡)
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 破骨細胞分化におけるRANKL依存的なHO-1発現抑制の役割2011

    • Author(s)
      坂井詠子
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKR博多(福岡)
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] RANKL依存的なHO-1発現抑制はHMGB1の遊離に必要である2011

    • Author(s)
      坂井詠子
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Kahweolの破骨細胞形成と骨吸収活性への影響2011

    • Author(s)
      文元玲子
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] tert-Butylhydroquinoneの破骨細胞形成と骨吸収活性への影響2011

    • Author(s)
      山口優
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Deltamethrinの破骨細胞形成と骨吸収活性への影響2011

    • Author(s)
      坂元裕
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nrf2活性化剤はRANKL誘導性破骨細胞分化を阻害する2011

    • Author(s)
      文元玲子
    • Organizer
      日本薬理学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] RANKL依存的HO-1発現抑制はHMGB1の遊離とカスパーゼ3の活性化につづく破骨細胞分化に必要である2011

    • Author(s)
      坂井詠子
    • Organizer
      日本薬理学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] フィセチンによる破骨細胞分化抑制作用2011

    • Author(s)
      菅原めぐみ,坂井詠子,西下一久,福間裕,岡元邦彰,吉田教明,筑波隆幸
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 破骨細胞分化におけるRANKL依存的なHO-1発現抑制の役割2011

    • Author(s)
      坂井詠子,菅原めぐみ,西下一久,福間 裕,岡元邦彰,筑波隆幸
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] アスパラギン酸プロテアーゼナプシンAおよびナプシンBの生化学的解析 (Biochemical analyses of napsin A and napsin B)2011

    • Author(s)
      西下一久, 坂井詠子,岡元邦彰,筑波隆幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] RANKL依存的なHO-1発現抑制はHMGB1の遊離に必要である (Suppression of RANKL-dependent HO-1 is required for HMGB1 release.)2011

    • Author(s)
      坂井詠子, 菅原めぐみ, 西下一久, 福間 裕, 岡元邦彰, 筑波隆幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] Deltamethrinの破骨細胞形成と骨吸収活性への影響 (Effects of deltamethrin on osteoclast formation and bone resorption.)2011

    • Author(s)
      坂元裕, 坂井詠子, 岡元邦彰, 筑波隆幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] tert-Butylhydroquinoneの破骨細胞形成と骨吸収活性への影響(Effects of tert-Butylhydroquinone on osteoclast formation and bone resorption.)2011

    • Author(s)
      山口優, 坂井詠子, 岡元邦彰, 筑波隆幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] Kahweol の破骨細胞形成と骨吸収活性への影響 (Effects of Kahweol on osteoclast formation and bone resorption.)2011

    • Author(s)
      文元玲子, 坂井詠子, 岡元邦彰, 筑波隆幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] Nrf2 activators inhibit osteoclastgenesis induced by receptor activator of NF-・B ligand2011

    • Author(s)
      Reiko Fumimoto, Hiroshi Sakamoto, Yu Yamaguchi, Eiko Sakai, Kuniaki Okamoto and Takayuki Tsukuba
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Receptor activator of NF-・B ligand dependent heme oxygenase-1 suppression is required for high mobility group box 1 release, caspase-3 activation, and subsequent osteoclastgenesis2011

    • Author(s)
      Eiko Sakai, Megumi Shimada, Kazuhisa Nishishita, Yutaka Fukuma, Kuniaki Okamoto and Takayuki Tsukuba
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] HO-1の発現誘導はRANKLを介したHMGB1の細胞外遊離と破骨細胞分化を阻害する2010

    • Author(s)
      坂井詠子
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] カテプシンE欠損における破骨細胞分化への影響2010

    • Author(s)
      岡元邦彰
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] HO-1はHMGB1の遊離を抑制し破骨細胞形成を阻害する2010

    • Author(s)
      坂井詠子
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] RANKL誘導性破骨細胞分化における遺伝子型の影響2010

    • Author(s)
      楢原峻
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] HO-1 の発現誘導はRANKLを介したHMGB1の細胞外遊離と破骨細胞分化を阻害する2010

    • Author(s)
      坂井詠子,西下一久,福間 裕,岡元邦彰,筑波隆幸
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] カテプシンE欠損における破骨細胞分化への影響2010

    • Author(s)
      岡元邦彰,坂井詠子,西下一久,福間 裕,坂 元 裕,文元玲子,山口 優,山本健二,筑波隆幸
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] RANKL 誘導性破骨細胞分化における遺伝子型の影響2010

    • Author(s)
      楢原 峻,松島春菜,坂井詠子,筑波隆幸
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] HO-1はHMGB1の遊離を抑制し破骨細胞形成を阻害する2010

    • Author(s)
      坂井詠子,嶋田めぐみ,西下一久,福間 裕,岡元邦彰,中山浩次,筑波隆幸
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      松戸
    • Related Report
      2012 Final Research Report
  • [Presentation] アスパラギン酸プロテアーゼナプシンの比較遺伝学的分析と生化学的解析2010

    • Author(s)
      西下一久,坂井詠子,岡元邦彰,筑波隆幸
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      松戸
    • Related Report
      2012 Final Research Report
  • [Presentation] カテプシン群によるメンブレントラフィックへの影響2010

    • Author(s)
      筑波隆幸,岡元邦彰
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      松戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription factor Sp1 regulates the expression of the murine cathepsin E gene in gastric adenosarcoma cells2010

    • Author(s)
      Kuniaki Okamoto, Yoshiko Okamoto, Tomoyo Kawakubo, Kenji Yamamoto, Takayuki Tsukuba
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] Autophagy impairment associated with increased aberrant mitochondria and oxidative stress in cathepsin E-deficientmacrophage2010

    • Author(s)
      Takayuki Tsukuba, Michiyo Yanagawa, Tomoko Kadowaki, Yoshiko Okamoto, Kuniaki Okamoto, Kenji Yamamoto
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Book] 現代歯科薬理学 第5版2012

    • Author(s)
      筑波隆幸(14、25章 執筆)、岡元邦彰(16章、20章 執筆)、(加藤有三、篠田壽 監修、大谷啓一、鈴木邦明、戸苅彰史編)
    • Publisher
      医歯薬出版
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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