| Project/Area Number |
22592080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
|
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 癌 / MALT1 / 細胞増殖 / 浸潤 / 細胞周期 / MALT1遺伝子 / 細胞増殖能 / 質量分析 / 発現ベクター / 浸潤・転移能 |
|---|
| Research Abstract |
Mucosa-associated lymphoid tissue 1 (MALT1) is a major player in lymphocyte activation and modulates NF-kB signaling pathways through its scaffolding function. We studied the role of MALT1 in the oral carcinoma cells. In the first study, we analyzed alterations of protein expression in response to MALT1 in oral carcinoma cells with proteomics analysis. Four different keratins, K8/18 and K5/14 were identified in MALT1-expressing and-negative HSC2 cells. K5/14 is an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased K5/14 expression correlates with tumorigenic progression.
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