Study on development of a novel remedy using green tea catechin for Sjogren's syndrome
| Project/Area Number |
22592082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Keiichi 東北大学, 大学院・歯学研究科, 助教 (00178477)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Shiro 東北大学, 病院, 講師 (80230069)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 緑茶カテキン / シェーグレン症候群 / Bax / Bcl-2 / MRL/lprマウス / 活性酸素 / JNK / MKP2 |
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| Research Abstract |
We administered epigallocatechin gallate (EGCG) to MRL-Faslprmice from age of 8 to 16weeks and examined suppressive effects of EGCG on autoimmune sialadenitis. Our results demonstrated that the rate of sialadenitis accompanied with tissue destruction decreased in EGCG-administered mice by 70% relative to EGCG-non-administered mice. The protective actions ofEGCG were ascribed to expression of heme oxygenase-1 and Bcl-2 which was enhanced by EGCG.
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Report
(4 results)
Research Products
(13 results)
