Study on development of a novel remedy using green tea catechin for Sjogren's syndrome

• Project/Area Number: 22592082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: SAITO Keiichi 東北大学, 大学院・歯学研究科, 助教 (00178477)
• Co-Investigator(Kenkyū-buntansha): MORI Shiro 東北大学, 病院, 講師 (80230069)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 緑茶カテキン / シェーグレン症候群 / Bax / Bcl-2 / MRL/lprマウス / 活性酸素 / JNK / MKP2

Research Abstract

We administered epigallocatechin gallate (EGCG) to MRL-Faslprmice from age of 8 to 16weeks and examined suppressive effects of EGCG on autoimmune sialadenitis. Our results demonstrated that the rate of sialadenitis accompanied with tissue destruction decreased in EGCG-administered mice by 70% relative to EGCG-non-administered mice. The protective actions ofEGCG were ascribed to expression of heme oxygenase-1 and Bcl-2 which was enhanced by EGCG.

Research Products

• [Journal Article] Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas^<lpr> mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2 (2013)
  • Author(s): Keichi Saito, Shiro Mori (他2名)
  • Journal Title: Autoimmunity Volume: (in press)
  • Peer Reviewed
• [Journal Article] Sjogren'ssyndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and4-1BB ligand (2013)
  • Author(s): Keiichi Saito, Shiro Mori(他2名)
  • Journal Title: Autoimmunity Volume: 46 Issue: 4 Pages: 231-237
  • DOI: 10.3109/08916934.2012.757307
  • Peer Reviewed
• [Journal Article] Mouse model of lymphonode metastasis via afferent lymphatic vessels fordevelopment of imaging modelities (2013)
  • Author(s): Shiro Mori (他4名)
  • Journal Title: Plos One Volume: 8 Issue: 2 Pages: e55797-e55797
  • DOI: 10.1371/journal.pone.0055797
  • Peer Reviewed
• [Journal Article] Epigallocatechin gallate disturbs thymidineglycol formation induced by oxidative stress in Sjogren's syndrome-like autoimmune sialadenitis of MRL/lpr mice (2011)
  • Author(s): Keiichi Saito, Shiro Mori(他2名)
  • Journal Title: Interface Oral Health Science Pages: 153-155
• [Journal Article] Evaluation of antitumoreffects following tumor necrosis factor-alphagene delivery using nanobubbles and ultrasound (2011)
  • Author(s): Shiro Mori(他4名)
  • Journal Title: Cancer Sci Volume: 102 Issue: 11 Pages: 2082-2089
  • DOI: 10.1111/j.1349-7006.2011.02084.x
  • Peer Reviewed
• [Journal Article] Volumetric and Angiogenic Evaluation of Antitumor Effects with Acoustic Liposome and High-Frequency Ultrasound (2011)
  • Author(s): Tetsuya Kodama, Noriko Tomita, Yoko Yagishita, Sachiko Horie, Kenichi Funamoto, Toshiyuki Hayase, Maya Sakamoto, Shiro Mori
  • Journal Title: Cancer Research Volume: 71 Issue: 22 Pages: 6957-6964
  • DOI: 10.1158/0008-5472.can-11-2389
  • Peer Reviewed
• [Journal Article] Evaluation of antitumor effects following tumor necrosis factor-alpha gene delivery using nanobubbles and ultrasound (2011)
  • Author(s): Horie S, Watanabe Y, Ono M, Mori S, Kodama T
  • Journal Title: Cancer Sci Volume: 102 Pages: 2082-2089
  • Peer Reviewed
• [Journal Article] Development of localized gene delivery using a dual-intensity ultrasound system in the bladder. (2010)
  • Author(s): Horie S, Watanabe Y, Chen R, Mori S, et. al.
  • Journal Title: Ultrasound in Medicine and Biology Volume: 36(11) Pages: 1867-1875
  • Peer Reviewed
• [Presentation] 緑茶カテキン投与によるシェーグレン症候群類似唾液腺炎における酸化ストレス誘発物質発現に対する抑制効果 (2011)
  • Author(s): 齋藤恵一
  • Organizer: 日本口腔衛生学会
  • Place of Presentation: 松戸
• [Presentation] 緑茶カテキン投与によるシェーグレン症候群様唾液腺炎における酸化ストレス誘発物質に対する発現抑制効果 (2011)
  • Author(s): 齋藤恵一, 小関健由
  • Organizer: 第60回日本口腔衛生学会総会
  • Place of Presentation: 千葉県松戸市
• [Presentation] Epigallocatechin gallate disturbs thymidine glycol formation by oxidative stress in Sjogren's syndrome-like sialadenitis of MRL/lpr mice. (2011)
  • Author(s): Keiichi Saito, et. al.
  • Organizer: 第4回インターフェイス口腔科学国際シンポジウム
  • Place of Presentation: 仙台市
• [Presentation] MRL/lprマウスのシェーグレン症候群類似唾液腺炎におけるHO-1、Nox2の発現に対する緑茶カテキン投与の影響 (2010)
  • Author(s): 齋藤恵一
  • Organizer: 日本口腔衛生学会
  • Place of Presentation: 新潟
• [Book] Interface Oral Health Science 2011 (2011)
  • Author(s): Saito K, Mori S, Ono M, Koseki T
  • Publisher: Springer Tokyo