| Project/Area Number |
22592086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUKUMA Yutaka 長崎大学, 大学院・医歯薬学総合研究科, 教務職員 (50253688)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUBA Takayuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30264055)
OKAMOTO Kuniaki 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10311846)
NISHISHITA Kazuhisa 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20237697)
SAKAI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10176612)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病 / 上皮細胞 / リソソーム / 歯肉上皮細胞 / カテプシンC / ノックアウトマウス / 歯周病原性細菌 / 殺菌能 |
|---|
| Research Abstract |
Periodontitis is a bacterial infectious disease that destroys gingival epithelial cells, and develops inflammation of immune-related cells. However, pathological studies on epithelial cells in periodontitis have been less frequently performed compared to those of immune-related cells. In this study, we focused on lysosomal abnormalities, because gene mutants of lysosomal proteins such as cathepsin C and Lyst causes severe periodontal diseases in human．Therefore, we analyzed epithelial cells in cathepsin C deficient mice and Lyst mutant mice (beige mouse) infected by Porphyromonas gingivalis, a major periodontal pathogen, in order to clear the physiological and pathological roles of epithelial cells in periodontitis.
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