| Project/Area Number |
22592087
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HOTOKEZAKA Yuka 長崎大学, 病院, 講師 (10244089)
KATAYAMA Ikuo 長崎大学, 病院, 助教 (80295089)
SUMI Tadateru 長崎大学, 大学院・医歯薬学総合研究科, 助教 (80284701)
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | マイクロRNA / 細胞間情報交換 / ギャップ結合 / ストレス応答 / cPLA2α / マイクロＲＮＡ / cPLA2 |
|---|
| Research Abstract |
In this study, in order to know the role of miRNA upon cell response (ionizing radiation, UV, heat-shock, Hypoxia) to environmental stress and tried search miRNA known to try comprehensively analyzed to generate a library further. Relying on the presence or absence of cPLA2α we have studied for many years and analyzed by point gap junction further revealed. To get the completely cPLA2α knockout (KO) mice, we decided to produce a cPLA2α conditional KO mouse.
|
