| Project/Area Number |
22592088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Ikuo 長崎大学, 大学病院, 助教 (80295089)
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | hypoxia / ER stress / γ-taxilin / 細胞死 / hyoxia |
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| Research Abstract |
The purpoe of this study was to show that ER stress is related to the cell death of DNAdamage and to elucidate the mechanism. However, We have found thatγ-taxilin is downregulated and protein degradation of γ-taxilin occurs in hypoxia during the research. Therefore, the purpose was changed to clarify thatγ-taxilin is involved in the cell death caused by hypoxia. And it was found that cell death is caused by the degradation of γ-taxilin. In addition, the cell death was participated in the ER stress and mitochondoria pathway.
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