ER stress pathway in apoptosis of DNA damage
| Project/Area Number |
22592088
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Ikuo 長崎大学, 大学病院, 助教 (80295089)
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | hypoxia / ER stress / γ-taxilin / 細胞死 / hyoxia |
|---|
| Research Abstract |
The purpoe of this study was to show that ER stress is related to the cell death of DNAdamage and to elucidate the mechanism. However, We have found thatγ-taxilin is downregulated and protein degradation of γ-taxilin occurs in hypoxia during the research. Therefore, the purpose was changed to clarify thatγ-taxilin is involved in the cell death caused by hypoxia. And it was found that cell death is caused by the degradation of γ-taxilin. In addition, the cell death was participated in the ER stress and mitochondoria pathway.
|
Report
(4 results)
Research Products
(3 results)
