| Project/Area Number |
22592089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
HOTOKEZAKA Yuka 長崎大学, 大学病院, 講師 (10244089)
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
角 忠輝 長崎大学, 医歯(薬)学総合研究科, 助教 (80284701)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞老化 / FEN1 / p53 |
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| Research Abstract |
We identified that FEN1 inhibition lead to senescence in human bladder cancer cell line T24 and human fibroblast cell line BJ. On this occasion, expression of cell cycle related genes, DNA damage response, and unstable condition of DNA was caused. On the other hand, we recognized that FEN1 is binding to telomere involved in senescence, and related to telomere damage response. Furthermore, it was suggestedthat on senescence by FEN1 inhibition, there are p53-dependent and p53-independent manner.
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