Effect to immunoresponse of antibacterial peptides
Project/Area Number |
22592095
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Kagoshima University |
Principal Investigator |
KANBARA Kenji 鹿児島大学, 大学院・医歯学総合研究科, 助教 (60305141)
|
Co-Investigator(Kenkyū-buntansha) |
KOMATSUZAWA Hitoshi 鹿児島大学, 医歯学総合研究科, 教授 (90253088)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | LL-37 / LL37 / DNA / TLR9 / 歯周病態形成 / サイトカイン / TLR-9 |
Research Abstract |
In this study, it was demonstrated that LL-37 interacted with bacterial DNA/RNA and these complexes were tolerated to several nuclease. Furthermore, LL-37 interacted to apolipoprotein-A1(Apo-A1) which is a component of high density lipoprotein. It was considered that these complexes stimulate immune system effectively for a long time and LL-37-Apo-A1 complexes may be associated between metabolic syndrome. Those complexes tend to increase expression of CXCL10 in gingival epithelia cells, Ca9-22 cells. However, we have been not confirming increase of CXCL10 protein secretion level yet.
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Report
(4 results)
Research Products
(5 results)