The establishment of guidelines for diagnosis and treatment of xerostomia

• Project/Area Number: 22592096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: TANAKA Tatsurou 九州歯科大学, 歯学部, 准教授 (50326469)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 口腔乾燥症 / 唾液 / MRI / 診断 / 治療 / sialography / 機能 / シェーグレン症候群 / クエン酸

Outline of Final Research Achievements

We developed and clinically applied dynamic MR sialography as a new noninvasive diagnostic technique for the functional evaluation of salivary glands. We showed that dynamic MR sialographic images and data have a high potential as a diagnostic tool for Sjogren syndrome and xerostomia. In addition, we demonstrated that the high correlations were found between the changing ratio of the dynamic MR sialographic data, and improvement on clinical manifestations for dry mouth sensation after saline solution irrigation of the parotid glands and improvement of salivary flow rate in our study. We speculate that MR sialography could also predict the effectiveness of treatments for xerostomia other than the saline solution irrigation treatment.

Research Products

• [Journal Article] New approach for functional evaluation of swallowing by visualizing saline flow using high-speed continuous MRI based on T2-weighted sequences (2014)
  • Author(s): Tanaka T, Oda M, Nishimura S, Kito S, Wakasugi-Sato N, Kodama M, Kokuryo S, Habu M, Miyamoto I, Yamashita Y, Aso A, Sadasue K, Nagashima R, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 118 Issue: 4 Pages: 490-496
  • DOI: 10.1016/j.oooo.2014.05.014
  • Peer Reviewed
• [Journal Article] predict the success of local anesthetic block after initial treatment by the carbamazepine? (2014)
  • Author(s): Shiiba S, Tanaka T, Sakamoto E, Oda M, Kito S, Ono K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Imamura Y, Nakanishi O, Inenaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 117 Issue: 1 Pages: 15-21
  • DOI: 10.1016/j.oooo.2012.03.029
  • Peer Reviewed / Open Access
• [Journal Article] The significance of cone beam computed tomography for the visualization of anatomical variations and lesions in the maxillary sinus for patients hoping to have dental implant-supported maxillary restorations in a private dental office in Japan (2014)
  • Author(s): Shiki K, Tanaka T, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Oda M, Nishimura S, Morimoto Y
  • Journal Title: Head Face Med Volume: 10 Issue: 1 Pages: 20-20
  • DOI: 10.1186/1746-160x-10-20
  • Peer Reviewed / Open Access
• [Journal Article] Identification and adjustment of experimental occlusal interference using functional magnetic resonance imaging (2014)
  • Author(s): Oda M, Yoshino K, Tanaka T, Shiiba S, Makihara E, Miyamoto I, Nogami S, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Murakami K, Koga M, Kawagishi S, Yoshioka I, Masumi S, Kimura M, MorimotoY
  • Journal Title: BMC Oral Health Volume: 14 Pages: 124-124
  • Peer Reviewed / Open Access
• [Journal Article] Identification of peripheral vessels in oral and maxillofacial regions on magnetic resonance angiography obtained using a balanced steady-state free-precession sequence with a time-spatial labeling inversion pulse and using fresh blood imaging (2013)
  • Author(s): Oda M, Tanaka T, Yamashita Y, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Habu M, Kodama M, Uehara M, Kaneuji T, Kokuryo S, Miyamoto I, Yoshiga D, Seta Y, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 219 Issue: 6 Pages: 791-7
  • DOI: 10.1016/j.oooo.2013.09.016
  • Peer Reviewed
• [Journal Article] Significance and Utility of MR Cisternography for Diagnosis and Treatment of Trigeminal Neuralgia (2013)
  • Author(s): Tanaka T, Shiiba S, Sakamoto E, Oda M, Kito S, Ono K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Imamura Y, Watanabe S, Inenaga K, Morimoto Y
  • Journal Title: J Biomed Sci Eng Volume: 6 Issue: 03 Pages: 365-71
  • DOI: 10.4236/jbise.2013.63a046
  • Peer Reviewed
• [Journal Article] Alterations of the temporomandibular joint on magnetic resonance imaging according to growth and development in schoolchildren (2012)
  • Author(s): Tanaka T, Konoo T, Habu M, Oda M, Kito S, Kodama M, Kokuryo S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishida I, Morikawa K, Saeki K, Maki K, Tominaga K, Masumi S, Terashita M, Morimoto Y
  • Journal Title: Int J Dent Volume: 2012 Pages: 1-7
  • DOI: 10.1155/2012/695136
  • Peer Reviewed
• [Journal Article] 歯科用CBCTの臨床応用について (2012)
  • Author(s): 田中達朗, 小田昌史, 志岐一欣, 松本（武田）忍, 若杉（佐藤）奈緒, 鬼頭慎司, 森本泰宏
  • Journal Title: 九州歯会誌 Volume: 66 Pages: 125-130
  • NAID: 40019742162
  • Peer Reviewed
• [Journal Article] Noninvasive identification of peripheral vessels of oral and maxillofacial regions using electrocardiography-triggered three-dimensional fast asymmetric spin-echo sequences (2011)
  • Author(s): Tanaka T, et al
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 112 Pages: 493-501
  • Peer Reviewed
• [Journal Article] Correlation of mandibular bone quality with neurosensory disturbance after sagittal split ramus osteotomy (2011)
  • Author(s): Yoshioka I, Tanaka T, et al
  • Journal Title: Br J Oral Maxillofac Surg Volume: 49 Pages: 552-556
  • Peer Reviewed
• [Journal Article] Diagnostic significance of characteristic findings on ultrasonography for the stitch abscess after surgery in patients with oral squamous cell carcinoma. Oral Oncol (2011)
  • Author(s): Yamamoto N, Yamashita Y, Tanaka T, et al
  • Journal Title: Oral Oncol Volume: 47 Pages: 163-169
  • Peer Reviewed
• [Journal Article] Significance of dynamic MR sialography in prognostic evaluation for saline solution irrigation of the parotid gland as treatment of xerostomia (2010)
  • Author(s): Habu M, Tanaka T, Tomoyose T, Ono K, Ansai T, Ozaki Y, Yoshioka I, Yamashita Y, Kodama M, Yamamoto N, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Takahashi T, Inenaga K, Tominaga K, Morimoto Y
  • Journal Title: J Oral Maxillofac Surg Volume: 68 Pages: 768-76
  • Peer Reviewed
• [Journal Article] Relationship between inferior alveolar nerve canal positions at the mandibular second molar in patients with prognathism and the possible occurrence of neurosensory disturbance after sagittal split ramus osteotomy. (2010)
  • Author(s): Yoshioka I, Tanaka T, Khanal A, Habu M, Kito S, Kodama M, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Fukai Y, Tokitsu T, Tomikawa M, Seta Y, Tominaga K, Morimoto Y
  • Journal Title: J Oral Maxillofac Surg Volume: 68 Pages: 3022-7
  • Peer Reviewed
• [Journal Article] I Ultrasonography for intraoperative determination of tumor thickness and resection margin in tongue carcinomas. (2010)
  • Author(s): Kodama M, Khanal A, Habu M, Iwanaga K, Yoshioka I, Tanaka T, Morimoto Y, Tominaga K
  • Journal Title: J Oral Maxillofac Surg Volume: 68 Pages: 1746-52
  • Peer Reviewed
• [Journal Article] Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma. (2010)
  • Author(s): Wakasugi-Sato N, Wakasugi T, Oda M, Yamashita Y, Yoshioka I, Yamamoto N, Habu M, Kodama M, Kokuryo S, Ichimiya H, Miyamoto I, Tanaka T, Kito S, Matsumoto-Takeda S, Ishikawa A, Seta Y, Matsuo K, Takahashi T, Tominaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 68 Pages: 1746-52
  • Peer Reviewed
• [Presentation] T2強調画像を応用した超高速撮像MRIによる嚥下機能評価の試み (2014)
  • Author(s): 田中達朗 , 小田昌史 , 西村 瞬, 鬼頭慎司 , 松本（武田）忍 , 志岐一欣 , 若杉（佐藤）奈緒 , 村上慶太, 古賀正浩, 森本泰宏
  • Organizer: 日本歯科放射線学会第19回臨床画像大会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-01
• [Presentation] Magnetic resonance angiography with fresh blood imaging for identification of hemangiomas and around blood vessels in oral cavity (2014)
  • Author(s): Masafumi Oda, Tatsurou Tanaka, Shinji Kito, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Shun Nishimura, Yasuhiro Morimoto
  • Organizer: Asia-Pacific Conference
  • Place of Presentation: Kitakyushu
• [Presentation] 顎・顔面領域の末梢血管描出におけるFresh Blood Imaging法の有用性 (2013)
  • Author(s): 田中達朗, 小田昌史, 鬼頭慎司, 志岐一欣, 若杉（佐藤）奈緒, 松本（武田）忍, 大塚 梢, 森本泰宏
  • Organizer: 第54回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 福岡
• [Presentation] 歯科用コーンビームCTの歯科診療への応用ー 歯科用CBCTの臨床応用 ー (2012)
  • Author(s): 田中達朗
  • Organizer: 第72回九州歯科学会総会
  • Place of Presentation: 北九州
  • Invited
• [Presentation] 日常歯科臨床におけるCT、MRIの活用法 (2011)
  • Author(s): 田中達朗
  • Organizer: 日本小児歯科学会中四国・九州合同地方会第30回中四国地方会ミニセミナー
  • Place of Presentation: 北九州
  • Year and Date: 2011-10-09
• [Presentation] 口腔乾燥症唾液腺洗浄療法の予後予測におけるDynamic MR sialographyの有用性 (2011)
  • Author(s): 田中達朗, 鬼頭慎司, 小田昌史, 松本忍, 若杉奈緒, 大塚梢, 林祐樹, 深井康宏, 時津高俊, 志岐一欣, 森本泰宏
  • Organizer: 第16回日本歯科放射線学会臨床画像大会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-02
• [Presentation] 口腔乾燥症の病態解明と治療法選択基準の確立 (2011)
  • Author(s): 田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 尾崎由衛, 土生学, 兒玉正明, 宮本郁也, 山本哲彰, 森本泰宏
  • Organizer: 第71回九州歯科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2011-05-29
• [Presentation] Utility of ultrasonography for diagnosis if stitch abscess after surgery of oral cancer (2011)
  • Author(s): Tanaka T, Yamamoto N, Kito S, Matsumoto-Takeda S, Wakasugi-Sato N, Otsuka K, Oda M, Imamura Y, Haraoka T, Ono I, Nishio Y, Miyamoto I, Yamashita Y, Takahashi T, Morimoto Y
  • Organizer: The 18th International Congress of Dentomaxillofacial Radiology
  • Place of Presentation: Hiroshima
• [Presentation] Dynamic MR sialographyの臨床応用における有用性 (2010)
  • Author(s): 田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 廣松辰巳, 時津高俊, 深井康弘, 森本泰宏
  • Organizer: 第51回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 鶴見大学
• [Presentation] Dynamic MR sialographyの臨床応用について (2010)
  • Author(s): 田中達朗, 鬼頭慎司, 若杉奈緒, 小薗孝彰, 小田昌史, 小薗孝彰, 森本泰宏
  • Organizer: 第23回日本口腔診断学会総会
  • Place of Presentation: 日本大学松戸歯学部
• [Presentation] 頭頸部悪性腫瘍の術後に発症した縫合糸膿瘍の2例 (2010)
  • Author(s): 田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 滝野正義, 濱井祐昭, 時津高俊, 深井康弘, 内田朱美, 廣松辰巳, 森本泰宏
  • Organizer: 日本歯科放射線学会 第14回臨床画像大会
  • Place of Presentation: 鹿児島大学
• [Presentation] The utility of Dynamic MR sialography for dry month (2010)
  • Author(s): Tanaka T, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Oda M, Morimoto Y
  • Organizer: 第58回JADR学術大会
  • Place of Presentation: 九州歯科大学
• [Book] 「Q&A」で学ぶ歯科放射線学SBOs講義 (2011)
  • Author(s): 森本泰宏, 田中達朗
  • Publisher: 学建書院
• [Book] Application of CT for the study of pathology of the jaws. In CT imaing/Book 2 (2011)
  • Author(s): Tanaka T, et al
  • Publisher: In Tech Open access Publisher
• [Remarks] 九州歯科大学歯科放射線学分野
  • URL: http://www2.kyu-dent.ac.jp/depart/radiology/study.html
• [Remarks]
  • URL: http://www2.kyu-dent.ac.jp/depart/radiology/study.html
• [Remarks]
  • URL: http://www2.kyu-dent.ac.jp/depart/radiology/study.html