| Project/Area Number |
22592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Ikumi 岩手医科大学, 薬学部, 助教 (80509050)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIMURA Akira 岩手医科大学, 歯学部, 教授 (80173459)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / ナノバイオ / リンパ / DDS |
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| Research Abstract |
The aim of this study had been to developing novel liposome which had abilities of both controlled release and targeting lymph node in order to prevent metastasis caused by tongue cancer. The liposomal membrane was made strong by optimum lipid components. Then, the liposome was possible to delay the release time of drug and be decreased toxicity at injection site was inhibited. The liposome with low dose was able to improving beneficial effect and decreasing adverse effect. Furthermore, the drug in liposome accumulated to both tongue with primary tumor and lymph node which is metastasis site. In conclusion, it was expected that the liposome which had ability both targeting and controlled release was able to therapy of primary tumor, prevention of metastasis and relief adverse effect with low dose.
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