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New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristics

Research Project

Project/Area Number 22592100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKeio University

Principal Investigator

ASODA Seiji  慶應義塾大学, 医学部, 講師 (80296706)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Momoko  慶應義塾大学, 医学部, 研究員(非常勤) (50570967)
Co-Investigator(Renkei-kenkyūsha) SAYA Hideyuki  慶應義塾大学, 医学部, 教授 (80264282)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords実験腫瘍学 / 腫瘍生物学 / 口腔扁平上皮癌 / EMT / CD44
Research Abstract

Epithelial mesenchymal transition (EMT) and stem cell-like characteristics are important phenomena for predicting the degree of malignancy and treatment resistance of oral squamous cell carcinoma (OSCC) . CD44 is a major marker for stem-like cancer cells

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013

    • Author(s)
      Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
    • Journal Title

      Cancer Res

      Volume: 73(6) Issue: 6 Pages: 1855-1866

    • DOI

      10.1158/0008-5472.can-12-3609-t

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗VEGFモノクロナール抗体ベバシズマブの関与が疑われた顎骨壊死の1例2011

    • Author(s)
      安居孝純, 鬼澤勝弘, 兵藤朋子, 岩崎良太郎, 莇生田整治, 河奈裕正
    • Journal Title

      日本口腔科学会雑誌

      Volume: 60(1) Pages: 16-22

    • NAID

      10030270787

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Burkitt's lymphoma in a patient presenting with inferior alveolar nerve hypoesthesia in the absence of a regional tumor : A case report and review of the literature2010

    • Author(s)
      Chika Niizato, Seiji Asoda, Daisuke Araki, Kentaro Sugiyama, Shin Usuda, Taneaki Nakagawa, Hiromasa Kawana
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 22(3) Pages: 180-184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔癌細胞の腫瘍形成におけるCD44v-xCTの機能的役割2013

    • Author(s)
      吉川桃子, 永野修, 莇生田整治, 中川種昭, 河奈裕正, 佐谷秀行
    • Organizer
      第31回日本口腔腫瘍学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 口腔癌細胞の腫瘍形成におけるCD44v-xCTの機能的役割2013

    • Author(s)
      吉川 桃子
    • Organizer
      第31回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      秋葉原
    • Related Report
      2012 Annual Research Report
  • [Presentation] xCT シスチントランスポーターの阻害はCD44 バリアント陽性扁平上皮癌細胞の生体内における拡大を抑制する.2012

    • Author(s)
      吉川桃子, 永野修, 土橋賢治, 莇生田整治, 中川種昭, 佐谷秀行
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibition of xCT-mediated cystine transport supresses CD44v-expressing squamous cell carcinoma cells2012

    • Author(s)
      吉川 桃子
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口腔扁平上皮癌に対するCDDP/S-1併用術前化学療法の検討-CDDP/5-FU療法との比較-2010

    • Author(s)
      莇生田整治, 臼田慎, 他
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://dent-os.med.keio.ac.jp/KEIO/classroom/research/index.html

    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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