New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristics
| Project/Area Number |
22592100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Keio University |
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Principal Investigator |
ASODA Seiji 慶應義塾大学, 医学部, 講師 (80296706)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Momoko 慶應義塾大学, 医学部, 研究員(非常勤) (50570967)
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| Co-Investigator(Renkei-kenkyūsha) |
SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 実験腫瘍学 / 腫瘍生物学 / 口腔扁平上皮癌 / EMT / CD44 |
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| Research Abstract |
Epithelial mesenchymal transition (EMT) and stem cell-like characteristics are important phenomena for predicting the degree of malignancy and treatment resistance of oral squamous cell carcinoma (OSCC) . CD44 is a major marker for stem-like cancer cells
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume: 73(6)
Issue: 6
Pages: 1855-1866
DOI
Related Report
Peer Reviewed
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