The role of 11β-HSD1, an intracellular glucocorticoid-activating enzyme, in periodontal disease
| Project/Area Number |
22592105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUZAKI Hiroaki 琉球大学, 大学院・医学研究科, 教授 (00291899)
DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
NAGANO Yutaka 大阪歯科大学, 歯学部, 講師(非常勤) (80228048)
INAMI Kaoru 大阪歯科大学, 歯学部, 助教 (40548327)
NOTOHARA Yasuhiro 大阪歯科大学, 歯学部, 講師(非常勤) (10548324)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯周病 / メタボリックシンドローム / 11β-HSD1 / グルココルチコイド |
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| Research Abstract |
It has been suggested that 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1), a glucocorticoid-activating enzyme, plays an important role in metabolic syndrome. Although the relationship between periodontal disease and metabolic syndrome has been established, the involvement of 11β-HSD1 in periodontal disease has not been reported. This study was performed to elucidate the role of 11β-HSD1 in periodontal disease. As a result, a statistically significant increase of 11β-HSD1 mRNA expression was detected in the periodontal disease group compared with the controls. Furthermore, the depth of periodontal pockets significantly correlated with the increased expression of 11β-HSD1 mRNA. These results suggest that the increased expression of 11β-HSD1 may play a role in the progression of periodontal disease.
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Report
(4 results)
Research Products
(38 results)
