Developement of the method for biocompatible resin composite system utilizing with colloidan platinum nano -particles.

• Project/Area Number: 22592107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: NODA Mamoru 岩手医科大学, 歯学部, 教授 (10301889)
• Co-Investigator(Kenkyū-buntansha): SANO Hidehiko 北海道大学, 大学院・歯学研究科, 教授 (90205998) ; 中沖 靖子 北海道大学, 歯学研究科(研究院), 助教 (50302881)
• Co-Investigator(Renkei-kenkyūsha): NAKAOKI Yasuko 北海道大学, 大学院・歯学研究科, 助教 (50302881)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 保存修復学 / ラジカル / アポトーシス / 白金 / ナノコロイド / ストレス / 修復 / 白金ナノコロイド / 細胞 / 修復法

Research Abstract

Light cured dental resin composites were cured by utilizing free radicals. However, the radical sometimes alter intracellular metabolism and shows toxic effect. In the present study, the possibility of colloidal platinum nanoparticles, which have an ability to scavenge free radicals, to decrease cellular stress during curing light cured resin composites was investigated.

Research Products

• [Journal Article] Colloidal platinum nanoparticles increase mitochondrial stress induced by resin composite components (2011)
  • Author(s): Kachi H, Noda M, Wataha JC, Nakaoki Y, Sano H.
  • Journal Title: J Biomed Mater Res B Appl Biomater. Volume: 2 Pages: 193-8
  • Peer Reviewed
• [Journal Article] Colloidal platinum nanoparticles increase mitochondrial stress induced by resin composite components (2011)
  • Author(s): H.Kachi, M.Noda, et al
  • Journal Title: Journal of biomedical materials research B, applied biomaterials Volume: 96 Pages: 191-198
  • Peer Reviewed
• [Journal Article] Colloidal platinum nanoparticles increase mitochondrial stress induced by resin composite components. (2010)
  • Author(s): Kachi H, Noda M, Wataha JC, Nakaoki Y, Sano H.
  • Journal Title: J Biomed Mater Res B Appl Biomater. Volume: 96 Pages: 193-198
  • Peer Reviewed
• [Presentation] #3675 Effect of Colloidal Platinum Nano-particles on Monocytes. (2010)
  • Author(s): H. Kachi, M. Noda, Y. Nakaoki , H. Sano
  • Organizer: IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] Effect of colloidal platinum nano-particles on monocytes (2010)
  • Author(s): Kachi H, Noda M, Wataha JC, Nakaoki Y, Sano H.
  • Organizer: IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-14