| Project/Area Number |
22592112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAKI Keiko 東北大学, 大学院・歯学研究科, 助教 (90182419)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Takuichi 東北大学, 大学院・歯学研究科, 講師 (10303132)
MAYANAGI Gen 東北大学, 大学院・歯学研究科, 助教 (10451600)
SHIMAUCHI Hidetoshi 東北大学, 大学院・歯学研究科, 教授 (70187425)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯内療法学 / 口腔細菌 / 根尖性歯周炎 / PCR / 16S rRNA / 嫌気性菌 / 根管内細菌叢 / 16S ribosomal RNA / 微生物迅速検査 |
|---|
| Research Abstract |
Intracanal microflora with apical periodontitis was investigated using two rapid microbial cell counters, anaerobic culture, and PCR targeting 16S rRNA genes. Mechanical enlargement of the root canal combined with chemical disinfection could effectively reduce the pathogen, though some species were resistant to this conventional protocol. Also, there were species seemingly linked to apical symptom. Species-specific antimicrobial therapy might enhance minimum intervention in cases harboring such species.
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