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Relations between sensation and innervation of dental pulp in patients with hereditary sensory and autonomic neuropathy(HSAN).

Research Project

Project/Area Number 22592117
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MIWA Zenzo  東京医科歯科大学, 歯学部附属病院, 講師 (30157705)

Co-Investigator(Kenkyū-buntansha) SATO Tetsuji  鶴見大学, 歯学部, 教授 (10162447)
Co-Investigator(Renkei-kenkyūsha) KAKINO Satoko  東京医科歯科大学, 歯学部附属病院, 医員 (30516307)
INOUE Kouji  鶴見大学, 歯学部, 助教 (40097308)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords先天性無痛無汗症 / 歯髄電気診(EPT) / pre-pain感覚 / 神経支配 / 免疫染色法 / 透過光光電脈波法(TLP) / 歯髄神経分布 / pre-pain / 歯髄感覚 / 歯髄組織 / 透過型光電脈波法(TLP) / 痛覚 / 歯髄血流の測定
Research Abstract

By electrical pulp tester (EPT), patients with hereditary sensory and autonomic neuropathy (HSAN-IV)cases did not feel any sensation at all in their teeth, but HSAN-V cases felt the pre-pain sensation similar to a normal person. Only a few myelinated fibers were observed in HSAN-IVcases, on the other hand, many fibers were identified in the dental pulp of patients withHSAN-V. The present result shows that remarkably reduced pulpal innervation might induce congenitalinsensitivity to pain in HSAN-IV.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2013 2012 2011 2010 2006 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Epidemi- ology of hereditary sensory and autonomic neuropathy type IV and V in Japan.2013

    • Author(s)
      Haga N., Kubota M., Miwa Z.
    • Journal Title

      Am J Med Ge net A

      Volume: 161A Issue: 4 Pages: 871-874

    • DOI

      10.1002/ajmg.a.35803

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 先天性無痛無汗症児に発症した下顎骨骨髄炎の1例2011

    • Author(s)
      三輪全三、柿野聡子、上原奈緒子、土橋なつみ、今村由紀、高木裕三、黒原一人
    • Journal Title

      小児歯科学歯誌

      Volume: 49(1) Pages: 41-46

    • URL

      http://search.jamas.or.jp/link/ui/2011210449

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amputation of inferior alveolar nerve stimulates the formation of bone-like structures in the dental pulp of rats2011

    • Author(s)
      Suzuki K., Kuroda N.
    • Journal Title

      Tsurumi Univ. Dent. J.

      Volume: 37 Pages: 9-18

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 先天性無痛無汗症児に発症した下顎骨骨髄炎-歯髄診断に透過型光電脈波法(TLP)を応用した1例-2011

    • Author(s)
      三輪全三, 他
    • Journal Title

      小児歯科学雑誌

      Volume: 49(1) Pages: 41-46

    • NAID

      10028185996

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amputation of inferior alveolar nerve stimulates the formation of bone-like structures in the dental pulp of rats.2011

    • Author(s)
      Suzuki K., Kuroda N.
    • Journal Title

      Tsurumi Univ.Dent.J.

      Volume: 37 Pages: 9-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sensation and Innervation of Dental Pulp in Patients with CIPA2012

    • Author(s)
      Miwa Z., Kubodera T., Ikeda M., Inoue K, Sato T.
    • Organizer
      21th International Association for Disability and Oral Health (IADH)
    • Place of Presentation
      Melbourn(Australia)
    • Related Report
      2012 Final Research Report
  • [Presentation] Perception of pungent, taste and odor stimuli in thepatients with congenital insensitivity to pain with anhidrosis(CIPA).2012

    • Author(s)
      Tsuchihashi N., Uehara N., Miwa Z., Takagi Y., Sugimoto K.
    • Organizer
      16th International Symposium on Olfaction and Taste (ISOT)
    • Place of Presentation
      Stockholm(Sweden)
    • Related Report
      2012 Final Research Report
  • [Presentation] Sensation and Innervation of Dental Pulp in Patients with CIPA .2012

    • Author(s)
      Z. Miwa , T. Kubodera, M.. Ikeda, T. Sato.
    • Organizer
      21th. International Association for Disability and Oral Health (IADH)
    • Place of Presentation
      Melbourne
    • Related Report
      2012 Annual Research Report
  • [Presentation] Perception of pungent, taste and odor stimuli in the patients with congenital insensitivity to pain with anhidrosis (CIPA)2012

    • Author(s)
      N. Tsuchihashi, N. Uehara, Z.Miwa, Y. Takagi, K.. Sugimoto.
    • Organizer
      16th. International Symposium on Olfaction and Taste (ISOT)
    • Place of Presentation
      Stockholm
    • Related Report
      2012 Annual Research Report
  • [Presentation] 誤抜歯により再植された上顎中切歯歯胚の予後経過-透過型光電脈波法(TLP)による歯髄血流の変化-2011

    • Author(s)
      三輪全三, 柿野聡子, 上原奈緒子, 土橋なつみ, 高木裕三
    • Organizer
      第49回日本小児歯科学会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 宿題委託研究報告、先天性無痛無汗症ライフステージに即した歯科的支援-実態把握とガイドライン作成を目指して-、先天性無痛無汗症の歯髄感覚と歯髄神経分布2011

    • Author(s)
      三輪全三
    • Organizer
      第28回日本障害者歯科学会
    • Place of Presentation
      博多
    • Year and Date
      2011-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 宿題依託研究報告,先天性無痛無汗症のライフステージに即した歯科的支援-実態把握とガイドライン作成を目指して-「無痛無汗症の歯髄感覚と歯髄神経分布」2011

    • Author(s)
      三輪全三
    • Organizer
      第28回日本障害者歯科学会
    • Place of Presentation
      博多
    • Year and Date
      2011-11-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先天性無痛(無汗)症における味覚および辛味感覚の感受性について2011

    • Author(s)
      上原奈緒子、土橋なつみ、三輪全三、高木裕三、杉本久美子
    • Organizer
      第58回小児保健協会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 先天性無痛(無汗)症患者における味覚および辛味感覚の感受性について2011

    • Author(s)
      上原奈緒子, 土橋なつみ, 三輪全三, 高木裕三, 杉本久美子
    • Organizer
      第58回小児保健協会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯髄血液酸素飽和度測定による新たな歯髄診断への試み2011

    • Author(s)
      柿野聡子, 三輪全三, 高木裕三, 櫛引真也, 松浦祐司
    • Organizer
      第50回日本生体医工学学会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下顎骨骨髄炎を発症した先天性無痛無汗症の腐骨範囲の決定にTLP(透過光光電脈波法)が有効であった1例2010

    • Author(s)
      三輪全三、柿野聡子
    • Organizer
      秋季日本小児歯科学会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 下顎骨骨髄炎を発症した先天性無痛無汗症児の腐骨範囲の決定にTLP(透過光光電脈波法)が有効であった1例2010

    • Author(s)
      三輪全三、柿野聡子, 他
    • Organizer
      秋季日本小児歯科学会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Objective pulp vitality test in apatient with CIPA using transmitted-light plethysmography2010

    • Author(s)
      Miwa Z., Kakino S., Sato T
    • Organizer
      20th International Association for Disability and Oral Health (IADH)
    • Place of Presentation
      Ghent(Belgium)
    • Year and Date
      2010-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Objective pulp vitality test in a patient with CIPA using transmitted-light plethysmography.2010

    • Author(s)
      Miwa Z, Kakino S., Sato T., et al.
    • Organizer
      20th.IADH(国際障害者歯科学会)
    • Place of Presentation
      ゲント(ベルギー)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Book] 先天性無痛無汗症、口から診える症候群・病気2012

    • Author(s)
      三輪全三
    • Publisher
      日本障害者歯科学会編
    • Related Report
      2012 Final Research Report
  • [Book] 口から診える症候群・病気: 「先天性無痛無汗症」2012

    • Author(s)
      三輪全三:  池田正一, 黒木良和 監修,
    • Total Pages
      244
    • Publisher
      日本障害者歯科学会編
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京医科歯科大学産学連携推進本部シーズ集一覧

    • URL

      http://www.tmd.ac.jp/tlo/visitor/ip/seeds/

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京医科歯科大学産学連携推進本部シーズ集一覧

    • URL

      http://www.tmd.ac.jp/tlo/visitor/ip/seeds/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 歯髄腔内血液測定方法、装置及び歯髄腔内血液測定用アダプタ2012

    • Inventor(s)
      三輪全三、柿野聡子、井川資英、高谷節雄、大内克洋、星英男、高木裕三、桐本明子
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Acquisition Date
      2012-01-20
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 歯髄の血流測定に関する技術2006

    • Inventor(s)
      三輪全三, 他
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-06-21
    • Acquisition Date
      2012-01-20
    • Related Report
      2011 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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