| Project/Area Number |
22592117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIWA Zenzo 東京医科歯科大学, 歯学部附属病院, 講師 (30157705)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tetsuji 鶴見大学, 歯学部, 教授 (10162447)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINO Satoko 東京医科歯科大学, 歯学部附属病院, 医員 (30516307)
INOUE Kouji 鶴見大学, 歯学部, 助教 (40097308)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 先天性無痛無汗症 / 歯髄電気診(EPT) / pre-pain感覚 / 神経支配 / 免疫染色法 / 透過光光電脈波法(TLP) / 歯髄神経分布 / pre-pain / 歯髄感覚 / 歯髄組織 / 透過型光電脈波法(TLP) / 痛覚 / 歯髄血流の測定 |
|---|
| Research Abstract |
By electrical pulp tester (EPT), patients with hereditary sensory and autonomic neuropathy (HSAN-IV)cases did not feel any sensation at all in their teeth, but HSAN-V cases felt the pre-pain sensation similar to a normal person. Only a few myelinated fibers were observed in HSAN-IVcases, on the other hand, many fibers were identified in the dental pulp of patients withHSAN-V. The present result shows that remarkably reduced pulpal innervation might induce congenitalinsensitivity to pain in HSAN-IV.
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