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Development of the method for prevention of dental caries with antibacterial ammonium hexafluorosilicate

Research Project

Project/Area Number 22592121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

SUGE Toshiyuki  徳島大学, 病院, 講師 (60243713)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kanako  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80403715)
Co-Investigator(Renkei-kenkyūsha) ISHIKAWA Kunio  九州大学, 大学院・歯学研究院, 教授 (90202952)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsスメア層 / フッ化ジアミンシリケート / フッ化ジアンミン銀 / フッ素 / 抗菌成分 / 象牙細管 / 齲蝕 / ハイドロキシアパタイト / 塩化セチルピリジニウム / 粉末X線回折 / 齲蝕予防 / S. mutans
Research Abstract

Diamine silver fluoride (Saforide) is clinical use for prevent of progress of dental caries and desensitizing for hypersensitive tooth. Unfortunately, diamine silver fluoride stained tooth black due to silver deposition. To overcome this drawback, ammonium hexafluorosilicatewas prepared. Comparing the antibacterial activity, ammonium hexafluorosilicate seems to be inferior to diamine silver fluoride. To increase the antibacterial activity of ammonium hexafluorosilicate, several antibacterial agents have been added to ammonium hexafluorosilicate solution. The antibacterial activity of ammonium hexafluorosilicate with the addition of antibacterial agents was increased, therefore, ammonium hexafluorosilicate is useful for prevention of dental caries.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (12 results)

  • [Journal Article] Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powder and enamel, Key Engineering Materials2013

    • Author(s)
      Suge T, Matsuo T
    • Journal Title

      Bioceramics 24

      Volume: Vols. 529-530 Pages: 526-530

    • DOI

      10.4028/www.scientific.net/kem.529-530.526

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate2012

    • Author(s)
      Suge T, Ishikawa K, Matsuo T
    • Journal Title

      American Journal of Dentistry

      Volume: 25 Pages: 299-302

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries2012

    • Author(s)
      Shibata S, Suge T, Kimura T, Ishikawa K, Matsuo T
    • Journal Title

      American Journal of Dentistry

      Volume: 25 Pages: 31-34

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reinforcement of bond strength of self-etching orthodontic adhesive2012

    • Author(s)
      Horiuchi S, Kuroda S, Hiasa M, Suge T, Saku S, Hamada K, Matsuo T, Asaoka K, Tanaka E
    • Journal Title

      The Angle Orthodontist

      Volume: 82 Issue: 1 Pages: 30-35

    • DOI

      10.2319/012011-39.1

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries2011

    • Author(s)
      Shibata S, Suge T, Ishikawa K, Matsuo T
    • Journal Title

      American Journal of Dentistry

      Volume: 24 Pages: 148-152

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion of dentin tubules with antibacterial ammonium hexafluorosllicate solution for the prevention of dentin caries2011

    • Author(s)
      Shibata S, et al
    • Journal Title

      American Journal of Dentistry

      Volume: 24 Pages: 148-152

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries2011

    • Author(s)
      Shibata S., et al.
    • Journal Title

      American Journal of Dentistry

      Volume: 24(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate2010

    • Author(s)
      Suge T, Kawasaki A, Ishikawa K, Matsuo T, Ebisu S
    • Journal Title

      Dental Materials

      Volume: 26 Issue: 1 Pages: 29-34

    • DOI

      10.1016/j.dental.2009.08.011

    • NAID

      10024178761

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] フッ化ジアミンシリケートを利用した象牙質知覚過敏症治療法の開発2010

    • Author(s)
      菅俊行
    • Journal Title

      四国歯学会雑誌

      Volume: 22 Pages: 149-155

    • NAID

      120005823502

    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powder and enamel2012

    • Author(s)
      Suge T
    • Organizer
      Bioceramics 24
    • Place of Presentation
      九州大学医学部百年講堂 (福岡県)
    • Year and Date
      2012-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Ammonium hexafluorosilicate with antimicrobial agents for the prevention of caries2012

    • Author(s)
      Matsuo T
    • Organizer
      90thGeneral Session & Exhibition of the IADR
    • Place of Presentation
      Iguacu convention center (ブラジルイグアス)
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dental caries2011

    • Author(s)
      Suge T
    • Organizer
      The 13thJoint-Scientific meeting between JSCD and KACD
    • Place of Presentation
      白凡記念館(韓国ソウル)
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗菌成分添加フッ化ジアミンシリケートが S. mutans の初期付着、バイオフィルム形成に与える影響2011

    • Author(s)
      柴田眞吾
    • Organizer
      第134回日本歯科保存学会
    • Place of Presentation
      東京ベイ舞浜ホテルクラブリゾート(千葉県)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Changes of crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate2011

    • Author(s)
      Suge T
    • Organizer
      International Dental Materials Congress 2011 (IDMC2011) 第57回日本歯科理工学会大会・2011 Annual Meeting of KRSDM)
    • Place of Presentation
      Yonsei University(韓国ソウル)
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Changes of crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate2011

    • Author(s)
      Suge T, et al
    • Organizer
      International Dental Materials Congress 2011
    • Place of Presentation
      延世大学(ソウル、韓国)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Addition of antimicrobial agent increased antibacterial activity of ammonium hexafluorosilicate2010

    • Author(s)
      S. Shibata
    • Organizer
      88thGeneral Session & Exhibition of the IADR
    • Place of Presentation
      Center Conventions International Barcelona(スペインバルセロナ)
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powder2010

    • Author(s)
      Suge T
    • Organizer
      88thGeneral Session & Exhibition of the IADR
    • Place of Presentation
      Center Conventions International Barcelona(スペインバルセロナ)
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powde2010

    • Author(s)
      Suge T., et al.
    • Organizer
      88th General Session & Exhibition of the IADR
    • Place of Presentation
      バルセロナ、スペイン
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗菌成分を添加したフッ化ジアミンシリケートの抗菌性評価2010

    • Author(s)
      柴田眞吾
    • Organizer
      第132回日本歯科保存学会
    • Place of Presentation
      崇城大学市民ホール(市民会館)(熊本県)
    • Year and Date
      2010-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of ammonium hexafluorosilicate concentration on crystallinity of hydroxyapatite powder and enamel

    • Author(s)
      Suge T
    • Organizer
      Bioceramics 24
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ammonium hexafluorosilicate with antimicrobial agents for the prevention of caries

    • Author(s)
      Matsuo T
    • Organizer
      90th General Session & Exhibition of the IADR
    • Place of Presentation
      Iguacu falls (ブラジル)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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