Establishment of therapeutic strategy for endo-perio lesion; the control of complement regulatory factors
| Project/Area Number |
22592124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKUTA Tetsuya 鹿児島大学, 大学院・医歯学総合研究科, 助教 (20284888)
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| Co-Investigator(Renkei-kenkyūsha) |
TORII Mitsuo 鹿児島大学, 医歯学総合研究科, 教授 (30116066)
OYAMA Tohru 鹿児島大学, 医歯学総合研究科, 助教 (60233623)
MIYASHITA Keiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (50636264)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯内治療学 / 歯内-歯周疾患 / 補体 / 歯髄細胞 / 補体制御因子 / MMP-2 |
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| Research Abstract |
Complement regulatory factors (CD46, CD55, and CD59) were expressed in human periodontal ligament cells. The amount of CD59 expressed on human periodontal ligament cells stimulated with LPS from P. intermediais down-regulated by pre-treatment with TNF- . Anandamide (AEA), one of endocannabinoids, induced MMP-2 production in human dental pulp cells. MMP-2 might be cleave the complement regulatory factors from cells, and which receive complementary attack. It is likely that inflammatory mediatorssuch as TNF- and endocannabinoids such as AEA down-regulate the expression of complement regulatory factors and might be cause the tissue destruction inapical region.
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Report
(4 results)
Research Products
(6 results)
