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Establishment of therapeutic strategy for endo-perio lesion; the control of complement regulatory factors

Research Project

Project/Area Number 22592124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionKagoshima University

Principal Investigator

SAKUTA Tetsuya  鹿児島大学, 大学院・医歯学総合研究科, 助教 (20284888)

Co-Investigator(Renkei-kenkyūsha) TORII Mitsuo  鹿児島大学, 医歯学総合研究科, 教授 (30116066)
OYAMA Tohru  鹿児島大学, 医歯学総合研究科, 助教 (60233623)
MIYASHITA Keiko  鹿児島大学, 医学部・歯学部附属病院, 助教 (50636264)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯内治療学 / 歯内-歯周疾患 / 補体 / 歯髄細胞 / 補体制御因子 / MMP-2
Research Abstract

Complement regulatory factors (CD46, CD55, and CD59) were expressed in human periodontal ligament cells. The amount of CD59 expressed on human periodontal ligament cells stimulated with LPS from P. intermediais down-regulated by pre-treatment with TNF- . Anandamide (AEA), one of endocannabinoids, induced MMP-2 production in human dental pulp cells. MMP-2 might be cleave the complement regulatory factors from cells, and which receive complementary attack. It is likely that inflammatory mediatorssuch as TNF- and endocannabinoids such as AEA down-regulate the expression of complement regulatory factors and might be cause the tissue destruction inapical region.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Anandamide induces matrix metalloproteinase-2 production through cannabinoid-1 receptor and transient receptor potential vanilloid-1 in human dental pulp cells in culture2012

    • Author(s)
      Miyashita K, Oyama T, Sakuta T, Tokuda M, Torii M
    • Journal Title

      J Endod

      Volume: 38 Issue: 6 Pages: 786-790

    • DOI

      10.1016/j.joen.2012.02.025

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 高浸透圧下でのマウス象牙芽細胞における細胞内転写因子と炎症性因子の発現2013

    • Author(s)
      藤沢真理、徳田雅行、森本陽子、小山徹、作田哲也、宮下桂子、鳥居光男
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      熊本
    • Year and Date
      2013-06-05
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト歯髄細胞培養系においてアナンダマイドは Cannabinoid-1 receptor Transient receptor potential vanilloid-1を介して MMP-2 産生を誘導する2012

    • Author(s)
      宮下桂子、小山徹、作田哲也、森本陽子、藤沢真理、徳田雅行、鳥居光男
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      沖縄
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト歯肉線維芽細胞における TNF-α誘導性の MMP-1 産生に対するインクレチン関連薬の影響2012

    • Author(s)
      徳田雅行、作田哲也、小山徹、梶原武弘、達山祥子、川上克子、森本陽子、江本真規子、藤沢真理、宮下桂子、藤島慶、鳥居光男
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      沖縄
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト歯肉線維芽細胞におけるTNF-α誘導性のMMP-1産生に対するインクレチン関連薬の影響2012

    • Author(s)
      徳田雅行
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト歯髄細胞培養系においてアナンダマイドはCannabinoid-1 receptor, Transient receptor potential vanilloid-1を介してMMP-2産生を誘導する2012

    • Author(s)
      宮下桂子
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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