| Project/Area Number |
22592147
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthetic dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
|
|---|
| Research Collaborator |
KAMANO Yuya 大阪大学, 大学院・歯学研究科, 大学院生
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 破骨細胞 / カルシニューリン / PICK1 / シグナル伝達 / ペプチド |
|---|
| Research Abstract |
Novel molecular mechanisms and molecular targets for osteoclastogenesis could form the basis for effective therapeutic strategies against alveolar bone resorption. We previously identified PICK1 (protein interacting with C kinase) as a novel calcineurin B-binding protein that modulates NFAT activity in neuron-like PC12 cells. In this study, we found that PICK1 binds to calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation via the activation of calcineurin-NFAT signaling. The novel molecular target PICK1 may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.
|
