Development of bone resorption inhibitors/drugs targeting signaling molecule PICK1
| Project/Area Number |
22592147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
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| Research Collaborator |
KAMANO Yuya 大阪大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 破骨細胞 / カルシニューリン / PICK1 / シグナル伝達 / ペプチド |
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| Research Abstract |
Novel molecular mechanisms and molecular targets for osteoclastogenesis could form the basis for effective therapeutic strategies against alveolar bone resorption. We previously identified PICK1 (protein interacting with C kinase) as a novel calcineurin B-binding protein that modulates NFAT activity in neuron-like PC12 cells. In this study, we found that PICK1 binds to calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation via the activation of calcineurin-NFAT signaling. The novel molecular target PICK1 may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.
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Report
(4 results)
Research Products
(9 results)
