The role of galectin-1 as a novel stress marker in serum and saliva

• Project/Area Number: 22592158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Maebashi Institute of Technology
• Principal Investigator: KADOYA Toshihiko 前橋工科大学, 工学部, 教授 (40551875)
• Co-Investigator(Kenkyū-buntansha): SASAGURI Kenichi 神奈川歯科大学, 歯学部, 講師 (10235286)
• Co-Investigator(Renkei-kenkyūsha): HORIE Hidenori 神奈川歯科大学, 歯学部, 客員教授 (80046135)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ストレス / ガレクチン-1 / プロテオーム

Research Abstract

The in vivo experiments using the restraint stress model demonstrated the stress-induced increase of Galectin-1 (GAL-1) in serum is regulated by the sympathetic nervous system. The GAL-1 levels in thymus and spleen increased and the level in muscle decreased at 30 min after the restraint stress, while there was no change in the mRNA levels of the organs.

Research Products

• [Journal Article] Oxidized galectin-1 tempers the LPS-induced increase of pro-inflammatory cytokine mRNA in cultured macrophages. (2011)
  • Author(s): Y. Kogawa, K. Nakajima, K. Sasaguri, N.Hamada, H. Kawasaki, S. Sato, T. Kadoya, H. Horie
  • Journal Title: Clinical, Cosmetic and Investigational Dentistry Volume: 3 Pages: 1-8
  • Peer Reviewed
• [Journal Article] The Galectin-1 level in serum as a novel marker for stress. (2010)
  • Author(s): M. Iwamoto, C. Taguchi, K. Sasaguri,K. Kubo, H. Horie, T. Yamamoto, M.Onozuka, S. Sato and T. Kadoya
  • Journal Title: Glycoconjugate Journal Volume: 27 Pages: 419-425
  • Peer Reviewed
• [Presentation] ストレス負荷による生体組織中のガレクチン-1 含量の変動解析 (2012)
  • Author(s): 門屋利彦, 岩本真由子, 小泉創, 堀江秀典, 越野江利子, 宮原初美, 山本利春, 笹栗健一
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] GDNFはRET-PI3K経路を介してDRGニューロンの神経突起伸長ならびにGalectin-1の発現を誘導する (2012)
  • Author(s): 高久静香, 柳澤比呂子, 渡部和彦, 中別府雄作, Francoise Poirier, 堀江秀典 , 門屋利彦 , 三五一憲
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] ストレス負荷による生体組織中のガレクチン-1含量の変動解析 (2012)
  • Author(s): 門屋利彦, 岩本真由子, 小泉創, 堀江秀典, 越野江利子, 宮原初美, 山本利春, 笹栗健一
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-12-16
• [Presentation] ガレクチン-1および酸化型ガレクチン-1刺激マクロファージタンパク質のプロテオーム解析 (2012)
  • Author(s): 宮本大、松浦遼太郎、堀江秀典、門屋利彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] Restraint Stress affects Galectin-1 Level in Serum and Organs of Adult Rats (2012)
  • Author(s): T. Kadoya, M. Iwamoto, S. Koizumi, H. Horie, E. Koshino, T. Yamamoto, K. Sasaguri
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-12
• [Presentation] Restraint Stress affects Galectin-1 Level in Serum and Organs of Adult Rats (2012)
  • Author(s): T. Kadoya, M. Iwamoto, S. Koizumi, H. Horie, E. Koshino, T. Yamamoto, K. Sasaguri
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: Ernest N. Morial Convention Center(New Orleans, USA)
  • Year and Date: 2012-10-12
• [Presentation] 酸化型ガレクチン-1刺激によるマクロファージタンパク質のプロテオーム解析 (2012)
  • Author(s): 宮本大、松浦遼太郎、堀江秀典、門屋利彦
  • Organizer: 日本生化学会関東支部例会
  • Place of Presentation: 前橋
  • Year and Date: 2012-06-26
• [Presentation] GDNFによるDRGニューロンの神経突起伸長促進ならびにgalectin-1発現誘導のメカニズム (2011)
  • Author(s): 三五一憲、柳澤比呂子、堀江秀典、門屋利彦
  • Organizer: 第21回日本病態生理学会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-20
• [Presentation] Proteomics for macrophages stimulated by oxidized or reduced galectin-1, or bovine serum albumin (2010)
  • Author(s): K. Yoshimura, F. Kametani, T. Miyazaki, H.Suzuki, Y.Sakamoto, M.Kato, M. Nishina, M.Suzuki, K.Kitamura, T. Kadoya
  • Organizer: 40th Annual Meeting Society for Neuroscience
  • Place of Presentation: Washington DC(USA)
  • Year and Date: 2010-11-14
• [Presentation] 新規ストレスマーカーとしての血清中Galectin-1の検討 A serum Galectin-1 as a new marker for stress (2010)
  • Author(s): 岩本真由子、田口千穂、笹栗健一、山本利春、堀江秀典、門屋利彦、佐藤貞夫、小野塚實
  • Organizer: 第33回日本神経科学会Neuroscience2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 新規ストレスマーカーとしての血清中Galectin-1の検討 (2010)
  • Author(s): 門屋利彦, 他
  • Organizer: 第33回日本神経科学会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-09-04
• [Presentation] 酸化型ガレクチン-1による神経損傷後の修復機構 Repair mechanism regulated by oxidized galectin-1 after nerve injury (2010)
  • Author(s): 堀江秀典、 古川幸枝、中島仰、 笹栗健一、濱田信城、川崎陽久、門屋利彦、佐藤貞夫
  • Organizer: 第33回日本神経科学会 Neuroscience2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Book] Galectin-1 as a multifunctional molecule in the peripheral nervous system after injury" Chapter 3 in Basic Principles of Peripheral Nerve Disorders (edited by Seyed Mansoor Rayegani) (2012)
  • Author(s): K. Sango, H. Yanagisawa, K. Watabe, H. Horie, T. Kadoya
  • Publisher: InTech d.o.o., Rijeka, Croatia