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The function of miRNAs in the atrophy of tongue and masticatory muscles with aging and searching for the treatment

Research Project

Project/Area Number 22592171
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionTsurumi University

Principal Investigator

SUGA Takeo  鶴見大学, 歯学部, 講師 (40247333)

Co-Investigator(Kenkyū-buntansha) YAMANE Akira  鶴見大学, 歯学部, 教授 (20166763)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯科補綴学一般 / 舌 / miRNA / Antisense / Real-time PCR / In situ hybridization / SDA-PAGE / in situ hybridization / 老齢マウス / 胎仔マウ / miR-1 / ミオシン重鎖 / non-coding RNA / 胎仔 / miR-24 / 加齢変化
Research Abstract

The present study attempt to elucidate the function of miRNAs in the atrophy of tongue and masticatory muscles with aging and to explore the treatment. The miRNA play significant roles in the development of tongue and masticatory muscles and might provide the muscle atrophy with very useful treatment for the muscle atrophy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010 Other

All Journal Article (30 results) (of which Peer Reviewed: 29 results) Presentation (5 results)

  • [Journal Article] Role of occlusion in mouse masseter muscleacetylcholine receptor clustering.2013

    • Author(s)
      MORI, M., NARIYAMA, M., ABO, T., HIRAI, S., OGAWA, T., HAMADA, Y., YAMANE, A. and ASADA, Y.
    • Journal Title

      J. Dent. Res.

      Volume: 92(4) Pages: 352-357

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of occlusion in mouse masseter muscle acetylcholine receptor clustering2013

    • Author(s)
      MORI, M., NARIYAMA, M., ABO, T., HIRAI, S., OGAWA, T., HAMADA, Y., YAMANE, A. and ASADA, Y.
    • Journal Title

      J. Dent. Res.

      Volume: 92 Issue: 4 Pages: 352-357

    • DOI

      10.1177/0022034513476038

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles2013

    • Author(s)
      KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
    • Journal Title

      Gerodontology

      Volume: 未定 Issue: 1 Pages: 56-62

    • DOI

      10.1111/ger.12004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the lack of teeth and the expression of myosins in masticatory muscles of microphthalmic mouse.2012

    • Author(s)
      NARIYAMA, M., KOTA, Y., KANEKO, S., ASADA, Y. and YAMANE, A.
    • Journal Title

      Cell Biochem. Func.

      Volume: 30(1) Pages: 82-88

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The function of platelet derived growth factor in the differentiation of mouse tongue striated muscle.2012

    • Author(s)
      SUZUKI, E., AOYAMA, K., FUKUI, T., NAKAMURA, Y. and YAMANE, A.
    • Journal Title

      Orthod. Craniofac.

      Volume: Res.15(1) Pages: 39-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a b2-adrenergic agonist.2012

    • Author(s)
      ABO, T., IIDA, R., KANEKO, S., SUGA, T.,YAMADA, H., HAMADA, Y. and YAMANE, A.
    • Journal Title

      CellBiochem. Func.

      Volume: 30(8) Pages: 671-676

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between the lack of teeth and the expression of myosins in masticatory muscles of microphthalmic mouse2012

    • Author(s)
      NARIYAMA, M., KOTA, Y., KANEKO, S., ASADA, Y. and YAMANE, A.
    • Journal Title

      Cell Biochem. Func.

      Volume: 30 Issue: 1 Pages: 82-88

    • DOI

      10.1002/cbf.1821

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The function of platelet derived growth factor in the differentiation of mouse tongue striated muscle2012

    • Author(s)
      SUZUKI, E., AOYAMA, K., FUKUI, T., NAKAMURA, Y. and YAMANE, A.
    • Journal Title

      Orthod. Craniofac. Res.

      Volume: 15 Issue: 1 Pages: 39-51

    • DOI

      10.1111/j.1601-6343.2011.01535.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a b2-adrenergic agonist2012

    • Author(s)
      ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y. and YAMANE, A.
    • Journal Title

      Cell Biochem. Func.

      Volume: 30 Issue: 8 Pages: 671-676

    • DOI

      10.1002/cbf.2848

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging.2011

    • Author(s)
      IIDA, R., KANEKO, S., SUGA, T., MORITO, M. and YAMANE, A.
    • Journal Title

      Mol. Cell. Biochem.

      Volume: 348(1) Pages: 89-98

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein-2 functions as a negative regulator, but not as an inducer for the formations of cartilage and bone in cultured tongue, in the differentiation of myoblasts in mouse embryonic tongue.2011

    • Author(s)
      AOYAMA, K., YAMANE, A., SUGA, T., SUZUKI, E., FUKUI, T. and NAKAMURA, Y.
    • Journal Title

      BMC Dev.

      Volume: Biol. Pages: 11-44

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition, biogenesis in the mitochondria of the soleus muscle in obese rats.2011

    • Author(s)
      KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M. and YAMANE, A.
    • Journal Title

      Anat.

      Volume: Rec.294(11) Pages: 1904-1912

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging2011

    • Author(s)
      IDA, R., KANEKO, S., SUGA, T., MORITO, M., YAMANE, A.
    • Journal Title

      Mol.Cell.Biochem.

      Volume: 348 Issue: 1-2 Pages: 89-98

    • DOI

      10.1007/s11010-010-0642-z

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein-2 functions as a negative regulator, but not as an inducer for the formations of cartilage and bone in cultured tongue, in the differentiation of myoblasts in mouse embryonic tongue2011

    • Author(s)
      AOYAMA, K., YAMANE, A., SUGA, T., SUZUKI, E., FUKUI, T., NAKAMURA, Y.
    • Journal Title

      BMC Dev.Biol.

      Volume: 44 Issue: 1 Pages: 11-11

    • DOI

      10.1186/1471-213x-11-44

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition, biogenesis in the mitochondria of the soleus muscle in obese rats2011

    • Author(s)
      KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M., YAMANE, A.
    • Journal Title

      Anat.Rec.

      Volume: 294 Issue: 11 Pages: 1904-1912

    • DOI

      10.1002/ar.21472

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the expression of myosins during postnatal development of masseter muscle in the microphthalmic mouse.2010

    • Author(s)
      KATAYMA, R., YAMANE, A. and FUKUI, T.
    • Journal Title

      Open Dent.

      Volume: J. 4:1-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGFb3 is expressed in differentiating muscle of the embryonic mouse tongue.2010

    • Author(s)
      YAMANE, A. FUKUI, T., SUGA, T., IIDA, R. and MORITO, M.
    • Journal Title

      Int. J. Dev.

      Volume: Biol.54(1) Pages: 221-226

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13.2010

    • Author(s)
      FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y. and YAMANE, A.
    • Journal Title

      Anat.

      Volume: Rec. 293(8) Pages: 1408-1415

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the classic 1 week glycogen-loading regimen on the fat-loading in the rat and human.2010

    • Author(s)
      SHINOHARA, A., TAKAKURA, J., YAMANE, A. and SUZUKI, M.
    • Journal Title

      J. Nutr. Sci.

      Volume: Vitaminol.56(5) Pages: 299-304

    • NAID

      10026966065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice.2010

    • Author(s)
      NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A. andASADA, Y.
    • Journal Title

      Pediatric Dent. J.

      Volume: 20(2) Pages: 122-129

    • NAID

      10027485798

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the lingual muscles of obese rats induced by high-fat diet.2010

    • Author(s)
      SAITO, T., YAMANE, A., KANEKO, S., OGAWA, T., IKAWA, T., SAITO, K. and SUGISAKI, M.
    • Journal Title

      Arch. Oral Biol.

      Volume: 55(10) Pages: 803-808

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the expression of myosins during postnatal development of masseter muscle in the microphthalmic mouse2010

    • Author(s)
      KATAYMA, R., YAMANE, A., FUKUI, T.
    • Journal Title

      Open Dent.J.

      Volume: 4 Pages: 1-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue2010

    • Author(s)
      YAMANE, A., FUKUI, T., SUGA, T., IIDA, R., MORITO, M.
    • Journal Title

      Int.J.Dev.Biol.

      Volume: 54 Pages: 221-226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-132010

    • Author(s)
      FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
    • Journal Title

      Anat.Rec.

      Volume: 293 Pages: 1408-1415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klotho遺伝子突然変異マウス骨格筋におけるインスリン様増殖因子およびその受容体mRNA発現2010

    • Author(s)
      飯田良平、菅武雄、山根明、森戸光彦
    • Journal Title

      鶴見歯学雑誌

      Volume: 36 Pages: 95-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the classic 1 week glycogen-loading regimen on the fat-loading in the rat and human2010

    • Author(s)
      SHINOHARA, A., TAKAKURA, J., YAMANE, A., SUZUKI, M.
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: 56 Pages: 299-304

    • NAID

      10026966065

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice2010

    • Author(s)
      NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
    • Journal Title

      Pediatric Dent.J.

      Volume: 20 Pages: 122-129

    • NAID

      10027485798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles.

    • Author(s)
      KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
    • Journal Title

      Gerodontology

      Volume: (In press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β2-adrenergic agonist

    • Author(s)
      ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y., YAMANE, A.
    • Journal Title

      Cell Biochem.Func.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the lingual muscles and volume of upper airway in obese rats

    • Author(s)
      SAITO, T., YAMANE, A., KANEKO, S., OGAWA, T., IKAWA, T., SAITO, K., SUGISAKI, M.
    • Journal Title

      Arch.Oral Biol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
  • [Presentation] Klothoマウスの舌、咬筋のサルコペニア発症にオートファジー蛋白質分解系が機能している2012

    • Author(s)
      山根明、飯田良平、金子周平、菅武雄、森戸光彦
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Changes in the property of rat genioglossus, geniohyoid and masseter muscles in assoication with aging2011

    • Author(s)
      YAMANE, A., KANEKO, S., IIDA, R., SUGA, T., MORITO, M.
    • Organizer
      第43回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット咬筋、オトガイ舌筋、オトガイ舌骨筋の老化過程におけるミオシン重鎖の発現変化2011

    • Author(s)
      金子周平、飯田良平、菅武雄、山根明、森戸光彦
    • Organizer
      日本老年歯科医学会第22回学術大会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cooperative functions of myostatin and IGF in the regulatory mechanism for the hypertrophy of rat masseter muscle induced with clenbuterol, a β2-adrenergic agonist2011

    • Author(s)
      YAMANE, A., ABO, T., IIDA, R., SUGA, T., KANEKO, S., FUKUI, T.
    • Organizer
      International Conference on Muscle Wasting 2001
    • Place of Presentation
      Centro Stefano Franscini, Ascona, Switzerland
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット骨格筋において高脂肪食摂取によりトリアシルグルセロールの蓄積される筋線維タイプについて2010

    • Author(s)
      金子周平、飯田良平、菅武雄、山根明、森戸光彦
    • Organizer
      第21回日本老年歯科医学会総会・学術大会
    • Place of Presentation
      朱鷺メッセ、新潟コンベンションセンター
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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