Development of a novel bone induction method for dental implant based on the mechanism of fracture healing
| Project/Area Number |
22592172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tokyo Dental College (2011-2012)
Matsumoto Dental University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
二宮 禎 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 顎口腔機能学 / 骨折治癒 / インプラント / 骨芽細胞 / オッセオインテグレーション / 骨増生法 |
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| Research Abstract |
In this study, we focused on fracture-induced osteoblast precursor cells (FOPC), which are the cells accumulated at sites of fracture and committed to the osteoblast lineage, and attempted to establish a new bone induction method using a rat fracture model. Immunohistochemical examination showed the accumulation and proliferation of bone marrow-derived Thy-1 (CD90)-positive osteogenic cells, suggesting their possible involvement in fracture healing.
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Report
(4 results)
Research Products
(15 results)
