Fabrication of apatite bone substitutes designed on bone tissue compatibility

• Project/Area Number: 22592185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kyushu University
• Principal Investigator: MUNAR Melvin 九州大学, 歯学研究科(研究院), 学術研究員 (50432919)
• Project Period (FY): 2010-10-20 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨補填材 / アパタイト / 連通気孔

Research Abstract

In order to increase an ability of bone replacement for carbonate apatite bone substitutes, an integrated design including pore incorporation as well as chemical composition and crystallinity was examined in this study. 10wt% spherical PMMA particles was introduced into gypsum hardening body and burned out then subsequently hydrothermally treated with carbonate solution to obtain the precursor porous body consisting of calcite. The precursor could transform to carbonate apatite with enough handling property. In vivo experiment using rats indicated the incorporation of new bone into the pore structure of the obtained porous body. It was concluded that the present method using spherical PMMA particles would be useful to make design of porous structure for carbonate apatite bone substitutes.