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Analysis of bone morphogenesis using human dental pulp as biomaterial

Research Project

Project/Area Number 22592190
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ITO Katsutoshi  北海道医療大学, 歯学部, 助教 (50433438)

Co-Investigator(Kenkyū-buntansha) MURATA Masaru  北海道医療大学, 歯学部, 准教授 (00260662)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsヒト歯髄 / BMP / 骨形成 / fg-Hap / ヒト脱灰象牙質 (DDM)脱灰象牙質 (DDM) / 硬組織再生 / ヒト脱灰象牙質
Research Abstract

It was analyzed the tissue regeneration factor included in the human pulp tissue and dentin for reusing as biomaterial. In the result, it was revealed there existed many hard tissue relative factors and tissue regeneration factors in addition to BMPs, strong bone morphogenetic factor. It was affirmed that the materials using as carriers for dental pulp included BMP-2 and BMP-7, it was suggested they were useful as hard tissue regeneration.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (15 results)

  • [Journal Article] Surface Characteristics and Osteoinductivity of Biomimetic Ceramic Scaffolds、Bioceramics Journal2013

    • Author(s)
      Junichi Tazaki, Katsutoshi Ito
    • Journal Title

      Key Engineering Materials

      Volume: 529-530巻 Pages: 44-49

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of Human Blood Adsorption to Biomimetic Functionally Graded Hydroxyapatite.2013

    • Author(s)
      Junichi Tazaki, Katsutoshi Ito
    • Journal Title

      Bioceramic Journal, Key Engineering Materials

      Volume: 529-530 Pages: 44-49

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMPs as Adsorptive Proteins for Ceramic Scaffolds2012

    • Author(s)
      伊藤勝敏
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 808-812

    • DOI

      10.4028/www.scientific.net/kem.493-494.808

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acid-insoluble Human Dentin as Carrier Material for Recombinant Human BMP-22012

    • Author(s)
      村田勝、伊藤勝敏
    • Journal Title

      J Biomed Mater Res A

      Volume: 100 Pages: 571-577

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multinucleated giant cells for biomaterials-Ceramics and dentin collagen-2012

    • Author(s)
      村田勝、伊藤勝敏
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 310-314

    • DOI

      10.4028/www.scientific.net/kem.493-494.310

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMPs as Adsorptive Proteins for Ceramic Scaffolds2011

    • Author(s)
      K. Ito, M. Murata
    • Journal Title

      Key Engineering Materials

      Volume: 493-494巻 Pages: 808-812

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical and histo-morphometrical analyses of bone and cartilage induced by human decalcified dentin matrix and BMP-22011

    • Author(s)
      村田勝、伊藤勝敏
    • Journal Title

      Oral Biology Research

      Volume: 35 Pages: 9-14

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of functionally graded hydroxyapatite for large mandibular defects in adult rabbits2010

    • Author(s)
      吉本良太、村田勝
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 19巻 Pages: 33-42

    • NAID

      10030688314

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evaluation of a novel chitosan/HAp composite biomaterial as a carrier of rhBMP-22010

    • Author(s)
      柏崎晴彦、村田勝
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 19巻 Pages: 181-186

    • NAID

      10027422234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues2010

    • Author(s)
      村田勝、伊藤勝敏
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118巻 Pages: 438-441

    • NAID

      130000304764

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone induction of human tooth and bone crushed by newly developed automatic mill2010

    • Author(s)
      村田勝
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118巻 Pages: 434-437

    • NAID

      130000304763

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Microstructure and Bio-Absorption of the Hydroxyapatite Ceramics Modified by a Partial Dissolution-Precipitation Technique Using Supersonic Treatment.2010

    • Author(s)
      赤澤敏之、村田勝、伊藤勝敏
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118巻 Pages: 535-540

    • NAID

      130000304784

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bone Regeneration by Patient-own Demineralized Dentin Matrix2013

    • Author(s)
      Md. Arafat Kabir, Katsutoshi Ito
    • Organizer
      3rd National & International Dental Congress
    • Place of Presentation
      ダッカ(バングラデシュ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Surface Characteristics and Osteoinductivity of Biomimetic Ceramic Scaffolds2012

    • Author(s)
      Junichi Tazaki, Katsutoshi Ito
    • Organizer
      BIOCERAMICS 24
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Surface Characteristics and Osteoinductivity of Biomimetic Ceramic Scaffolds2012

    • Author(s)
      Junichi Tazaki, Katsutoshi Ito
    • Organizer
      BIOCERAMICS 24
    • Place of Presentation
      ダッカ(バングラデシュ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト象牙質・歯髄組織におけるBMP-2の検出2011

    • Author(s)
      伊藤勝敏
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      タワーホール船堀(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自家脱灰象牙質の即時移植と組織生検像2011

    • Author(s)
      藤井雅之、伊藤勝敏
    • Organizer
      第37回社団法人日本口腔外科学会北日本地方会
    • Place of Presentation
      日本歯科大学新潟生命歯学部(新潟県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMPs as Adsorptive Proteins for Ceramic Scaffolds2011

    • Author(s)
      伊藤勝敏
    • Organizer
      BIOCERAMICS 23
    • Place of Presentation
      イスタンブール(トルコ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immediate Autograft of Demineralized Dentin for Bone Regeneration2010

    • Author(s)
      村田勝
    • Organizer
      1^<st> International Conference of Tooth-Bone Banking
    • Place of Presentation
      ソウル大学(韓国)
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト歯髄組織における肝細胞増殖因子の発現2010

    • Author(s)
      伊藤勝敏、村田 勝
    • Organizer
      第19回 硬組織再生生物学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト歯髄組織における肝細胞増殖因子の発現2010

    • Author(s)
      伊藤勝敏、村田勝
    • Organizer
      第19回硬組織再生生物学会
    • Place of Presentation
      就実大学(岡山)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single standing implant in the region of immediate autograft of demineralized dentin matrices for bone augmentation2010

    • Author(s)
      Katsutoshi Ito, Masaru Murata
    • Organizer
      The 6th Asian Sciences Seminar in Taiwan
    • Place of Presentation
      台湾
    • Related Report
      2012 Final Research Report
  • [Presentation] Single standing implant in the region of immediate autograft of demineralized dentin matrices for bone augmentation2010

    • Author(s)
      伊藤勝敏、村田勝
    • Organizer
      The 6th Asian Sciences Seminar in Taiwan
    • Place of Presentation
      中山医学大学(台湾・台中)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bone Regeneration by Patient-own Demineralized Dentin Matrix

    • Author(s)
      Md. Arafat Kabir, Katsutoshi Ito
    • Organizer
      3rd National & International Dental Congress 、3rd National & International Dental Congress
    • Place of Presentation
      ダッカ(バングラデシュ)
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト象牙質・歯髄組織におけるBMP-2の検出

    • Author(s)
      伊藤勝敏、村田 勝
    • Organizer
      第65回 NPO法人 日本口腔科学会学術集会、第65回 NPO法人 日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] BMPs as Adsorptive Proteins for Ceramic Scaffolds

    • Author(s)
      K.Ito, M.Murata
    • Organizer
      BIOCERAMICS 23
    • Place of Presentation
      Turkey
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of perforated demineralized dentin matrix for bone regeneration in tri-cortical defects of sheep iliac

    • Author(s)
      Md. Arafat Kabir, Katsutoshi Ito
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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