Modulation of angiogensis in bone regeneration

• Project/Area Number: 22592197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nihon University
• Principal Investigator: SATO Shuichi 日本大学, 歯学部, 講師 (50225942)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 血管新生 / 骨 / 再生 / 移植・再生医療 / 骨再生 / 定量分析 / マイクロCT

Research Abstract

This study evaluated angiogenesis in rat non-critical and critical calvarial flat bone defects using in vivo micro-CT. Critical- and non-critical-sized calvarial bone defects showed bone regeneration and angiogenesis around the midsagittal suture. New blood vessel networks were observed around defects of both sizes. Angiogenesis preceded bone regeneration around critical- and non-critical-sized calvarialbone defects. Angiogenesis led to full bone formation in non-critical-sized defects

Research Products

• [Journal Article] Micro CT observation of angiogenesis in bone regeneration. (2012)
  • Author(s): Udagawa A, Sato S, Hasuike A, Arai Y, Ito K
  • Journal Title: Clin Oral Implants Res
  • Peer Reviewed
• [Journal Article] Effect of nicotine on boneaugmentation in rat calvarium (2012)
  • Author(s): Saito Y, Sato S, Oginuma T, Saito Y, Arai Y, Ito K
  • Journal Title: Clin OralImplants Res.
  • Peer Reviewed
• [Journal Article] Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap. (2012)
  • Author(s): Oginuma T, Sato S, Udagawa A, Saito Y, Arai Y, Ito K
  • Journal Title: Oral Surg Oral Med Oral Pathol OralRadiol Volume: 114
  • Peer Reviewed
• [Journal Article] Correlation in the densities of augmented and existing bone in guided bone augmentation. (2012)
  • Author(s): Yamada Y, Sato S, Yagi H, Ujiie H, Ezawa T
  • Journal Title: Clin Oral Implants Res Volume: 23 Pages: 837-845
  • Peer Reviewed
• [Journal Article] Micro CT observation of angiogenesis in bone regeneration (2012)
  • Author(s): Udagawa A
  • Journal Title: Clinical Oral Implants Research Volume: -
  • Peer Reviewed
• [Journal Article] α-リン酸三カルシウムセメントにおける培養骨芽細胞様細胞の付着および浸潤率について. (2011)
  • Author(s): 福山富久,佐藤秀一,石橋和也,汐見登,菅井健二,深瀬康公,伊藤公一
  • Journal Title: 日大歯学 Volume: 85 Pages: 23-28
  • NAID: 10031146263
  • Peer Reviewed
• [Journal Article] A comparative study of micro-CT and the histomorphometry in evaluating bone augmentation in ratcalvarium. (2010)
  • Author(s): Kochi G, Sato S, Ebihara H, Hirano J, Arai Y, Ito K
  • Journal Title: J Oral Sci Volume: 52 Pages: 203-211
  • Peer Reviewed
• [Journal Article] Effects of α-DT cement with hydroxypropylcellulose on bone augmentation within a titanium cap in the rabbit calvarium. (2010)
  • Author(s): Fukuyama T, Sato S, Fukase Y, Ito K
  • Journal Title: Dent Mater J Volume: 29 Pages: 160-166
  • Peer Reviewed
• [Presentation] SEM observation of angiogenesis in bone augmentation. (2012)
  • Author(s): Udagawa A
  • Organizer: 20^<th> European Association for Osseointegration
  • Place of Presentation: Copnehagen, Denmark
  • Year and Date: 2012-10-10
• [Presentation] Influence of nicotine concentration on bone augmentation (2012)
  • Author(s): Saito Y
  • Organizer: 20^<th> European Association for Osseointegration
  • Place of Presentation: Copnehagen,Denmark
  • Year and Date: 2012-10-10
• [Presentation] Bone regeneration by lactoferin in rat calvarial bone defects (2012)
  • Author(s): Yoshimaki T
  • Organizer: 98^<th>American Academy of Periodontology.
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2012-09-28
• [Presentation] 内側性骨欠損の血管新生に対するbFGFの効果 (2012)
  • Author(s): 木上理沙
  • Organizer: 第136回日本歯科保存学会学術大会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-06-28
• [Presentation] bFGFによるラット内側性骨欠損における血管新生および骨再生のエックス線・組織学的検討 (2012)
  • Author(s): 木上理沙
  • Organizer: 第64回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-20
• [Presentation] PDGFがラット頭頂骨におよぼす影響 (2012)
  • Author(s): 土屋紀子
  • Organizer: 第64回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-20
• [Presentation] ラット頭頂骨における骨外側方向への骨増生に対するPDGFの影響 (2012)
  • Author(s): 土屋紀子
  • Organizer: 第55回春季日本歯周病学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 2012-05-17
• [Presentation] ウサギGBAモデルにおいて増生した新生組織の移植骨としての検討 (2012)
  • Author(s): 津徳克成
  • Organizer: 第55回春季日本歯周病学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 2012-05-17
• [Presentation] Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap (2011)
  • Author(s): Oginuma T
  • Organizer: 97^<th>Americanan Academy of Periodontology
  • Place of Presentation: Florida,USA
  • Year and Date: 2011-11-12
• [Presentation] Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap (2011)
  • Author(s): Oginuma T
  • Organizer: 97^<th>Americanangiogenes ,Academy of Periodontology
  • Place of Presentation: Florida, USA
  • Year and Date: 2011-11-12
• [Presentation] 内側性骨欠損の血管新生および骨再生の動態観察 (2011)
  • Author(s): 宇田川麻美
  • Organizer: 日本大学歯学会
  • Place of Presentation: 日本大学歯学部大講堂(東京都)
  • Year and Date: 2011-05-21
• [Presentation] Micro-CT observation of angiogenesis in guided bone regeneration (2010)
  • Author(s): 宇田川麻美, 佐藤秀一, 伊藤公一
  • Organizer: 韓国歯周病学会
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2010-11-27
• [Presentation] Micro-CT observation of angiogenesis in guided bone regeneration. (2010)
  • Author(s): Udagawa A
  • Organizer: 50^<th>Korean Academy ofPeriodontology
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2010-10-30
• [Presentation] Effect of bone marrow penetration on the guided bone augmentation in the rat calvarium: comparative study of micro-CT and histomorphometry. (2010)
  • Author(s): Sato S
  • Organizer: 96^<th>American Academy of Periodontology
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-10-30
• [Presentation] The adhesion and infiltration of cultured osteoblast-like cells within α-DT and β-TCP. (2010)
  • Author(s): Fukuyama T
  • Organizer: 96^<th>American Academy of Periodontology
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-10-30
• [Presentation] 内側性骨欠損の血管新生および骨再生の動態観察 (2010)
  • Author(s): 宇田川麻美
  • Organizer: 第63回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] ラットGBAモデルを用いた自家骨と骨補填材の併用による骨外側方向への骨増生の影響 (2010)
  • Author(s): 荻沼毅
  • Organizer: 第53回春季日本歯周病学会学術大会
  • Place of Presentation: 岩手
  • Year and Date: 2010-05-13
• [Presentation] 骨外側方向への骨増生法に関する研究 (2010)
  • Author(s): 佐藤秀一
  • Organizer: 第33回臨床応用を目指した3次元臓器造形研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] SEM observation of angiogenesis in bone augmentation
  • Author(s): Sato S
  • Organizer: Eurpean Assocication for Osseointegration
  • Place of Presentation: Copenhagen (Denmark)
• [Presentation] 内側性骨欠損の血管新生に対するｂFGFの効果
  • Author(s): 佐藤秀一
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄）
• [Presentation] ｂFGFによるラット内側性骨欠損における血管新生および骨再生のエックス線・組織学的検討
  • Author(s): 佐藤秀一
  • Organizer: 日本大学歯学会
  • Place of Presentation: 日本大学歯学部（東京）