The development of the new bone regeneration therapy for the diabetic osteoporosis
| Project/Area Number |
22592201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKI Shigeru 松本歯科大学, 歯学部, 教授 (20134942)
KASAHARA Kaoru 松本歯科大学, 歯学部, 准教授 (20064694)
KAWAHARA Ichiro 松本歯科大学, 歯学部, 講師 (20319114)
中根 卓 松本歯科大学, 歯学, 講師 (70164241)
定岡 直 松本歯科大学, 歯学, 助手 (80549395)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBOKI Yosinori 北海道大学, 名誉教授 (00014001)
SHIROTA Tatsuo 昭和大学, 歯学部, 准教授 (60235760)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生歯学 / 糖尿病 / 骨再生 / 幹細胞 / 骨補填材 / ドラッグデリバリーシステム / BMP-2 / 骨粗鬆症 / 歯周病 / ドラッグテリバリーシステム |
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| Research Abstract |
Using diabetes mellitus / an osteoporosis complication model animal, we analyzed the factor which was necessary for a bone regeneration in the bone regeneration part limited part and performed this study for the purpose of developing bone regeneration medical treatment with the drug delivery system. An ostosis by Cal Sane and the alizarin was confirmed even if we employed it in the aperture of either carrier. And the bony formation in the honeycomb aperture was seen a lot in Col37H in comparison with 37H.Col37H compared the bone density with 37H in 1 week later, and density was slightly high. Elevation of the manifestation of BMP-2 in the periodontal disease alveolar part of mandible alveolar bone and VEGF was observed.
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Report
(4 results)
Research Products
(26 results)
