The influence of the sympathetic nerve system on the differentiation and pain of the masticatory muscles

• Project/Area Number: 22592203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SATO Jun 北海道大学, 北海道大学病院, 助教 (60319069)
• Co-Investigator(Kenkyū-buntansha): KITAGWA Yoshimasa 北海道大学, 大学院・歯学研究科, 教授 (00224957) ; YAMAZAKI Yutaka 北海道大学, 北海道大学病院, 講師 (90250464)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 咀嚼筋 / 筋痛 / 口腔顎顔面痛 / 交換神経系 / 顎顔面痛 / 交感神経 / 顎関節症

Research Abstract

The number of the patient with recurrent chronic orofacial pain is increasing. The main pathophysiology of the patients with chronic orofacial pain is muscle pain. We studied the relationships between the activities of sympathetic nerve system or influence of soft-diet and the differentiation or metabolic activities of the muscle fibers in the masticatory muscles. The animal experiences of the rabbit indicated that sympathetic nerve system may affect the differentiation or metabolic activities of the muscle fibers in the masticatory muscles. Moreover, necrosis of the muscle fibers of the side of sympathectomy might indicate the correlation with occurrence of the diseases such as muscular dystrophy. Another animal experience with growing rabbit indicated that soft-diet habit may also contribute to the differentiation or metabolic activities of the muscle fibers in the masticatory muscles. Clinical studies indicated that stimulation and inhibition of the sympathetic nerve system may affect the threshold of the pressure pain of the masticatory muscles. The degrees of the change of the threshold of the pressure pain of the muscles may depend on the pain of the orofacial region.

Research Products

• [Journal Article] The trend of difficult diagnosis of tetanus in Japan: report of a case and review of the literature (2013)
  • Author(s): Takehiko Satoh, Jun Sato, Takahiro Abe, Akira Satoh, Kenji Imamachi, Yoshimasa Kitagawa
  • Journal Title: Journal of Oral and Maxillofacial surgery, Medicine, and Pathology Volume: 25 Pages: 55-60
  • Peer Reviewed
• [Journal Article] The trend of difficult diagnosis of tetanus in Japan: report of a case and review of the literature. (2013)
  • Author(s): Takehiko Satoh
  • Journal Title: Journal of Oral and Maxillofacial surgery, Medicine, and Pathology Volume: 25 Issue: 1 Pages: 55-60
  • DOI: 10.1016/j.ajoms.2012.01.013
  • Peer Reviewed
• [Journal Article] Successful total mandibular reconstruction using fibular graft with long-term follow-up: a case report (2012)
  • Author(s): Takahiro Abe, Hideaki Kitada, Jun Sato, Yutaka Yamazaki, Ken-ichi Notani, Taihiko Yamaguchi, Yoshimasa Kitagawa
  • Journal Title: Asian J Oral Maxillofac Surg Volume: 23 Pages: 196-200
  • Peer Reviewed
• [Journal Article] Should pain be used as predictor of prognosis in oral squamous cell carcinomas (2012)
  • Author(s): Jun Sato, Yutaka Yamazaki, Akira Satoh,Makiko Onodera-Kyan, Takahiro Abe, Takehiko Satoh, Ken-ichi Notani, Yoshimasa Kitagawa. 佐藤淳
  • Journal Title: In reply Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 113 Pages: 423-4
  • Peer Reviewed
• [Journal Article] Successful total mandibular reconstruction using fiular graft with long-term follow-up : a case report (2012)
  • Author(s): Abe T, Sato J, et al.
  • Journal Title: Asian J Oral Maxillofacial Surg Volume: 23 Issue: 3 Pages: 196-200
  • DOI: 10.1016/j.ajoms.2011.01.003
  • Peer Reviewed
• [Journal Article] Ring fibers visualized by electron microscopy in a Japanese patient with malignant hyperthermia (2011)
  • Author(s): Yoshimasa Kitagawa, Jun Sato, Masaru Kuriyama, Kazuo Sano, Kenji Hashimoto
  • Journal Title: Odontology Volume: 99 Pages: 101-4
  • NAID: 10029303594
  • Peer Reviewed
• [Journal Article] Pain may predict poor prognosis in patients with oral squamous cell carcinoma (2011)
  • Author(s): Jun Sato, Yutaka Yamazaki, Akira Satoh, Makiko Onodera, DDS, PhD, Takahiro Abe, Takehiko Satoh, Ken-ichi Notani, Yoshimasa Kitagawa
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 111 Pages: 587-92
  • NAID: 120002989232
  • Peer Reviewed
• [Journal Article] Ring fibers visualized by electron microscopy in a Japanese patient with malignent hyperthemia (2011)
  • Author(s): Kitagawa Y, Sato J, et al.
  • Journal Title: Odontology Volume: 99 Pages: 101-104
  • Peer Reviewed
• [Journal Article] Oral health care reduces the risk of postoperative surgical site infection in inpatients with oral squamous cell carcinoma. (2011)
  • Author(s): Sato J, Goto J, et al.
  • Journal Title: Support Care Cancer Volume: 19巻 Pages: 409-416
  • Peer Reviewed
• [Journal Article] Ring fibers visualized by electron microscopy in a Japanese patient with malignant hyperthermia. (2011)
  • Author(s): Kitagawa Y, Sato J, et al.
  • Journal Title: Odontology. Volume: 99 Pages: 101-104
  • NAID: 10029303594
  • Peer Reviewed
• [Journal Article] Pain is associated with Endophytic Growth Pattern of Cancer in Patients with Oral Squamous Cell Carcinoma before Treatment. (2010)
  • Author(s): Jun Sato, Yutaka Yamazaki, Akira Satoh, Ken-ichi Notani, Yoshimasa Kitagawa
  • Journal Title: Odontology Volume: 98 Pages: 60-4
  • Peer Reviewed
• [Presentation] Unique characteristics of the masseter muscle in patient with jaw deformity (2012)
  • Author(s): Yoshimasa Kitagawa, Jun Sato
  • Organizer: Sustainability Weeks 2012
  • Place of Presentation: 北海道大学歯学部講堂(幌市)
  • Year and Date: 2012-09-15
• [Presentation] Unique Characteristics of the Masseter Muscle in Patients with Jaw Deformity (2012)
  • Author(s): Yoshimasa Kitagawa
  • Organizer: Sustainability Weeks 2012, Hokkaido University
  • Place of Presentation: 北海道大学 （札幌市）
  • Invited
• [Presentation] A case of tetanus appropriately managed by early diagnosis in oral medical clinic (2011)
  • Author(s): 佐藤淳
  • Organizer: 第二回アジア顎関節学会
  • Place of Presentation: 広島大学(広島市)
  • Year and Date: 2011-07-23
• [Presentation] A case of tetanus appropriately managed by early diagnosis in oral medicine clinic (2011)
  • Author(s): 佐藤淳
  • Organizer: 第二回アジア顎関節学会
  • Place of Presentation: 広島大学(広島市)
  • Year and Date: 2011-07-23
• [Presentation] 成長期のsoftdietがウサギの咬筋および内・外側翼突筋におよぼす影響について (2010)
  • Author(s): 佐藤淳
  • Organizer: 第12回日本顎関節学会学術大会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-24
• [Presentation] 成長期のsoft dietがウサギの咬筋および内・外側翼突筋におよぼす影響について (2010)
  • Author(s): 佐藤淳、北川善政, ら
  • Organizer: 第23回日本顎関節学会学術大会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-24
• [Presentation] 口腔扁平上皮癌患者の治療前の疼痛に関連する因子の研究 (2010)
  • Author(s): 佐藤淳
  • Organizer: 第48回日本口腔科学会学術集会
  • Place of Presentation: 札幌プリンスホテル(札幌市)
  • Year and Date: 2010-06-24
• [Presentation] 開口障害の精査依頼で受診した破傷風の1例 (2010)
  • Author(s): 阿部貴洋,佐藤淳
  • Organizer: 第48回日本口腔科学会北日本地方会
  • Place of Presentation: ネ!ットU仙台市情報・産業プラザ(仙台市)
  • Year and Date: 2010-05-21
• [Book] 歯科医療:口腔内科学的アプローチの現在;歯科医療に必要な口腔顎顔面痛の知識 (2010)
  • Author(s): 佐藤淳
  • Publisher: 第一歯科出版
• [Remarks] 北海道大学大学院歯学研究科口腔病態学講座口腔診断内科学教室ホームページ
  • URL: http://www.den.hokudai.ac.jp/kouge1/oralsurg1.html