• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The elucidation of a mechanotransduction mechanism to the joint destruction in the temporomandibular joint synovial cell

Research Project

Project/Area Number 22592204
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAkita University

Principal Investigator

TAKANO Hiroshi  秋田大学, 医学部, 助教 (30282172)

Co-Investigator(Renkei-kenkyūsha) FUKUDA Masayuki  秋田大学, 医学部, 准教授 (20272049)
NAGAI Hirokazu  徳島大学, ヘルスバイオサイエンス研究部, 准教授 (50282190)
NAKATA Akira  秋田大学, 医学部, 助教 (50400510)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsメカニカルストレス / 顎関節 / メカノトランスダクション / 培養滑膜細胞 / 破骨細胞 / 関節破壊
Research Abstract

In this study, the mechanical stress considered to participate in development of symptoms and advance of temporomandibular disorder was added to the human temporomandibular joint synovial cells, and the elucidation of the mechanotransduction mechanism in a synovial cell. Since the cultured cell became extinct under the influence of the Great East Japan Earthquake, although it did not result in the elucidation of sufficient signal transfer, promotion of formation and the mechanism of the osteoclast by compression stimulus of the synovial cells were clarified.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Presentation (8 results)

  • [Presentation] メカニカルストレスによる顎関節滑膜細胞を介した骨代謝メカニズムの解析2012

    • Author(s)
      高野裕史,高橋 哲,中田 憲,桑島精一,山崎雅人,福田雅幸
    • Organizer
      第57回(社)日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] メカニカルストレスによる顎関節滑膜細胞を介した骨代謝メカニズムの解析2012

    • Author(s)
      髙野裕史
    • Organizer
      第57回(社)日本口腔外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Osteoclast-like cells derived from joint-infiltrating cells in synovial fluid oftemporomandibular joint patients with condylar process fractures of mandible2011

    • Author(s)
      Hiroshi Takano, Tetsu Takahashi, Akira Nakata, Seiichi Kuwajima, Masayuki Fukuda
    • Organizer
      The 2^<nd> International and the 24^<th> Annual Meeting of the Japanese Society for the Temporomandibular Joint
    • Place of Presentation
      Hiroshima
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Osteoclast-like cells derived from joint-infiltrating cells in synovial fluid of temporomandibular joint patients with condylar process fractures of mandible2011

    • Author(s)
      Hiroshi Takano, Tetsu Takahashi, Akira Nakata, Seiichi Kuwajima, Masayuki Fukuda
    • Organizer
      The 2nd International and the 24th Annual Meeting of the Japanese Society for the Temporomandibular Joint
    • Place of Presentation
      Hiroshima
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト顎関節由来培養滑膜細胞における機械的圧縮ストレスのRANKL発現に及ぼす影響2010

    • Author(s)
      高野裕史、福田雅幸, 他
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉市
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 機械的圧縮ストレスがヒト顎関節由来培養滑膜細胞に及ぼす破骨細胞誘導メカニズムの解析2010

    • Author(s)
      高野裕史、福田雅幸, 他
    • Organizer
      第23回日本顎関節学会総会・学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 機械的圧縮ストレスがヒト顎関節由来培養滑膜細胞へ及ぼす破骨細胞誘導メカニズムの解析2010

    • Author(s)
      高野裕史,高橋 哲,永井宏和,中田 憲,伊藤 悠,福田雅幸
    • Organizer
      第23回日本顎関節学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト顎関節由来培養滑膜細胞における機械的圧縮ストレスのRANKL 発現に及ぼす影響2010

    • Author(s)
      高野裕史,高橋 哲,永井宏和,中田 憲,伊藤 悠,福田雅幸
    • Organizer
      第55回(社)日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi