Involvement of vascular elements in formation of articular cavity in temporomandibular joint
| Project/Area Number |
22592207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
ONO Kazuhiro 新潟大学, 医歯学系, 教授 (40224266)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941)
SUZUKI Akiko 新潟大学, 医歯学系, 特任助教 (70509538)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 顎関節 / 関節腔 / 発生 / 血管 / 関節円板 / 毛細血管 / 血管新生 / アポトーシス / GFAP / ネスチン / マクロファージ / 滑膜表層細胞 |
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| Research Abstract |
The upper articular cavity formation had begun in advance of the lower cavitation. In the area of the prospective upper articular cavity, the phagocytosis by ED1-positive macrophages expanded the intercellular spaces of mesenchymal cells to form the cleft between the temporal bone and articular disk at embryonic day 18. On the other hand, the CD31-positive endothelial cells were restricted to the lower cavity-forming area at embryonic day 19 to spread out the tissue between mandibular condylar and articular disk, and diminished thereafter. The appearance of ED1-reactive macrophages and temporal vascularization play crucial roles in the upper and lower articular cavity formation, respectively.
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Report
(4 results)
Research Products
(8 results)
