| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The upper articular cavity formation had begun in advance of the lower cavitation. In the area of the prospective upper articular cavity, the phagocytosis by ED1-positive macrophages expanded the intercellular spaces of mesenchymal cells to form the cleft between the temporal bone and articular disk at embryonic day 18. On the other hand, the CD31-positive endothelial cells were restricted to the lower cavity-forming area at embryonic day 19 to spread out the tissue between mandibular condylar and articular disk, and diminished thereafter. The appearance of ED1-reactive macrophages and temporal vascularization play crucial roles in the upper and lower articular cavity formation, respectively.
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