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Development of effective methods for regeneration of the periodontal ligament of cryopreserved teeth, for expansion of indications for tooth transplantation.

Research Project

Project/Area Number 22592209
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

泉 直也  新潟大学, 医歯学総合病院, 助教 (10361908)

Co-Investigator(Kenkyū-buntansha) KOJIMA Taku  新潟大学, 医歯学系, 助教 (90515777)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯の移植 / 凍結保存 / 歯根膜
Research Abstract

For expansion of indications for tooth transplantation, we examined the regeneration of the periodontal tissues after cryopreservation using a rat model. The maxillarymolars of rats were extracted and transplanted into the abdominal subcutaneous tissue either immediately or after cryopreservation. The cryopreserved teeth were thawed and transplanted after having done organ culture for a certain period of time. As for the cryopreserved tooth which it transplanted after having done organ culture, the improvement of the periodontal regenerative activity was not found clearly. We intend to improve culture method and are going to determine efficacy of the organ culture of the cryopreserved tooth and technical problems in future.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2013 2011

All Journal Article (3 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Autotransplantation or replantation of cryopreserved teeth: a case series and literature review2013

    • Author(s)
      Yoshizawa M, Koyama T, Izumi N, Niimi K, Ono Y, Ajima H, Funayama A, Mikami T, Kobayashi T, Ono K, Takagi R, Saito C
    • Journal Title

      Dent Traumatol

      Volume: Epub ahead of print Issue: 1 Pages: 71-75

    • DOI

      10.1111/edt.12039

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autotransplantation or replantation of cryopreserved teeth: a case series and literature review.2013

    • Author(s)
      Yoshizawa Michiko
    • Journal Title

      Dental Traumatology

      Volume: 10 MAR

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryopreservation and autotranasplantation of teeth2011

    • Author(s)
      Yoshizawa M, Izumi N, Koyama T, Ono Y, Niimi K, Sugai T, Kobayashi T, Ono K, Takagi R, Saito C
    • Journal Title

      Hiroshima University, International Industry-academia Collaboration Symposium

      Pages: 42-49

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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