Minimally invasive jawbone regeneration with adipose-derived mesenchymal stem cells
| Project/Area Number |
22592210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
ONO Yukiko 新潟大学, 医歯学総合病院, 助教 (80345511)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIZAWA Michiko 新潟大学, 医歯学系, 助教 (60303137)
IZUMI Naoya 新潟大学, 医歯学総合病院, 助教 (10361908)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔外科学一般 / 骨芽細胞 / 間葉系幹細胞 / 脂肪 / 骨 / 再生 / 骨髄 / 組織工学 / 生体材料 / 幹細胞 |
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| Research Abstract |
Adipose-derived mesenchymal stem cells were cultured in various osteogenic induction conditions, and the best culture condition was revealed. They were seeded in porous β-TCP blocks, and incubated in the best osteogenic induction condition. Adipose-derived stem cells/β-TCP block composites were implanted subcutaneously and harvested for histological analysis. Amount of newly formed bone in adipose-derived stem cells/β-TCP block composites increased slightly more than ever before, however it was less than that in bone marrow-derived stem cells/β-TCP block composites.
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Report
(4 results)
Research Products
(2 results)
