Minimally invasive jawbone regeneration with adipose-derived mesenchymal stem cells

Research Project

Project/Area Number	22592210
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Niigata University
Principal Investigator	ONO Yukiko 新潟大学, 医歯学総合病院, 助教 (80345511)
Co-Investigator(Kenkyū-buntansha)	YOSHIZAWA Michiko 新潟大学, 医歯学系, 助教 (60303137) IZUMI Naoya 新潟大学, 医歯学総合病院, 助教 (10361908)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	口腔外科学一般 / 骨芽細胞 / 間葉系幹細胞 / 脂肪 / 骨 / 再生 / 骨髄 / 組織工学 / 生体材料 / 幹細胞
Research Abstract	Adipose-derived mesenchymal stem cells were cultured in various osteogenic induction conditions, and the best culture condition was revealed. They were seeded in porous β-TCP blocks, and incubated in the best osteogenic induction condition. Adipose-derived stem cells/β-TCP block composites were implanted subcutaneously and harvested for histological analysis. Amount of newly formed bone in adipose-derived stem cells/β-TCP block composites increased slightly more than ever before, however it was less than that in bone marrow-derived stem cells/β-TCP block composites.