| Project/Area Number |
22592211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKITA Hiroki 岐阜大学, 大学院・医学系研究科, 講師 (50345790)
KATO Keizo 岐阜大学, 医学部附属病院, 講師 (40397336)
SHIBATA Toshiyuki 岐阜大学, 大学院・医学系研究科, 教授 (50226172)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / 癌 / 遺伝子 / 動物 |
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| Research Abstract |
We aim to examine the usefulness of 4-NQO induced rat tongue cancer as human oral carcinogenesis model .In order to verify whether changes in the overall level of H3K4,H3K9 histone methylation,the level of H3K4me3,H3K9me2,me3 were measured in 4-NQO induced rat tongue cancer model by western blotting.Our results suggest that the level of H3K9me2 was increased in squamous cell carcinoma of rat at 32 weeks from beginning of administration.Therefore, 4-NQO induced rat tongue cancer model is suggested the usefulness as human oral carcinogenesis model .
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