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Analysis of the early aberrant DNA methylation and influence of demethylation agent in the 4NQO-induced rat tongue cancer model

Research Project

Project/Area Number 22592212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionGifu University

Principal Investigator

KATO Keizo  岐阜大学, 医学部附属病院, 講師 (40397336)

Co-Investigator(Kenkyū-buntansha) HARA Akira  岐阜大学, 大学院・医学系研究科, 教授 (10242728)
SHIBATA Shibata  岐阜大学, 大学院・医学系研究科, 教授 (50226172)
MAKITA Hiroki  岐阜大学, 大学院・医学系研究科, 講師 (50345790)
YAMASHITA Tomomi  岐阜大学, 大学院・医学系研究科, 准教授 (80345793)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords癌 メチル化 / メチル化 / 癌 / 遺伝子
Research Abstract

Epigenetic alteration attracts attention of the carcinogenesis process. However, it is difficult to examine at early time without the lesion. Therefore we examined in4NQO-induced rat tongue carcinogenesis model. The gene examined p16 and MGMT .In addition, we examined epigallocatechin gallate (EGCG) about demethylating ability .As a result, the significant change of the methylation status did not occur in each period. However, slightly controlled tendency was seen in the protein level in EGCGgroup. By these results, the carcinogenesis agent does not bring the epigenetic alteration, immediately . It was shown that long-term sustained influence participated.Furthermore, the possibility was shown that EGCG was effective by the long-term dosage.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2013 2012 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Necrotic cervical nodes: Usefulness of diffusion-weighted MR imaging in the differentiation of suppurative lymphadenitis from malignancy2013

    • Author(s)
      Kato H, Kanematsu M, Kato Z, Teramoto T, Mizuta K, Aoki M, Makita H, Kato K
    • Journal Title

      Eur J Radiol

      Volume: 82 (1)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple bone cyst of the mandibular condyle in a child: report of a case2012

    • Author(s)
      Hatakeyama D, Tamaoki N, Iida K, Yonemoto K, Kato K, Makita H, Toida M, Shibata T
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 70(9) Pages: 2118-23

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis2012

    • Author(s)
      Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, Hara A, Hirose Y
    • Journal Title

      Carcinogenesis

      Volume: 33(3) Pages: 702-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.2012

    • Author(s)
      Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, KoizumiK, Maeda M, Ishimaru N, Ogawa I, Takata T.
    • Journal Title

      PLoS One

      Volume: 7(8)

    • NAID

      120006714446

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ヒト口腔扁平上皮がんにおける DNA メチル化異常の検討-擦過標本と組織標本の相関性-2012

    • Author(s)
      加藤恵三、玉置也剛、飯田一規、米本和弘、畠山大二郎、牧田浩樹、山下知巳、柴田敏之
    • Organizer
      第19回日本がん予防学会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] 4NQO 誘発ラット舌発癌モデルにおける遺伝子変異機構の解析2010

    • Author(s)
      牧田浩樹、加藤恵三、柴田敏之
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 4NQO 誘発ラット舌発癌モデルにおける遺伝子メチル化異常の解析2010

    • Author(s)
      牧田浩樹、米本和弘、 加藤恵三、畠山大二郎、山下知巳、柴田敏之
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] 4NQOラット舌発癌モデルにおける遺伝子変異機構の解析2010

    • Author(s)
      牧田浩樹
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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