| Project/Area Number |
22592213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Katsu 京都大学, 大学院・医学研究科, 准教授 (90314202)
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| Co-Investigator(Kenkyū-buntansha) |
BESSHO Kazuhisa 京都大学, 大学院・医学研究科, 教授 (90229138)
SHIMIZU Akira 京都大学, 大学院・医学研究科, 教授 (00162694)
SUGAI Manabu 京都大学, 大学院・医学研究科, 講師 (90303891)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯の再生 / 歯数制御 / 第3生歯 / 遺伝子治療 / USAG-1 / 分子標的治療 / BMP-7 / 歯牙再生 / BMP7 |
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| Research Abstract |
The basic dentition pattern observed in mammals is diphyodont, and consists of three incisors, one canine, four premolars, and three molars, while human teeth are diphyodont, excepting the permanent molars. The deciduous teethare, ontogenetically, the first generation of teeth. The permanent teeth (except the molars) belong to the second dentition. The term “third dentition” refers to theopinion that one more set of teeth can occur in addition to the permanent tooth. The epithelium which is considered as the anlagen of the third dentition develops lingual to all permanent tooth germs. Furthermore, when it appears, the prededecessor (permanent toothgerm) is in the bell-shaped stage. The time of appearance of the third dentition seemsto be after birth. This means that we have a chance to access the formation of the third dentition in the mouth.
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