Feasibility of gene therapy for tooth regeneration by stimulation of a third dentition
| Project/Area Number |
22592213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Katsu 京都大学, 大学院・医学研究科, 准教授 (90314202)
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| Co-Investigator(Kenkyū-buntansha) |
BESSHO Kazuhisa 京都大学, 大学院・医学研究科, 教授 (90229138)
SHIMIZU Akira 京都大学, 大学院・医学研究科, 教授 (00162694)
SUGAI Manabu 京都大学, 大学院・医学研究科, 講師 (90303891)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯の再生 / 歯数制御 / 第3生歯 / 遺伝子治療 / USAG-1 / 分子標的治療 / BMP-7 / 歯牙再生 / BMP7 |
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| Research Abstract |
The basic dentition pattern observed in mammals is diphyodont, and consists of three incisors, one canine, four premolars, and three molars, while human teeth are diphyodont, excepting the permanent molars. The deciduous teethare, ontogenetically, the first generation of teeth. The permanent teeth (except the molars) belong to the second dentition. The term “third dentition” refers to theopinion that one more set of teeth can occur in addition to the permanent tooth. The epithelium which is considered as the anlagen of the third dentition develops lingual to all permanent tooth germs. Furthermore, when it appears, the prededecessor (permanent toothgerm) is in the bell-shaped stage. The time of appearance of the third dentition seemsto be after birth. This means that we have a chance to access the formation of the third dentition in the mouth.
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Assessing anteroposterior basal bone discrepancy with the Dental Aesthetic Index2013
Author(s)
Huang B, Takahashi K, Yamazaki, T., Saito, K., Yamori, M.,Asai, K., Yoshikawa Y., Kamioka H.,, Yamashiro T., Bessho K
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Journal Title
Angle Orthod
Volume: 83
Issue: 3
Pages: 527-532
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process.2013
Author(s)
Huang, B., Takahashi, K., Sakata-Goto, T., Kiso, H., Togo, Y., Saito, K., Tsukamoto, H., Sugai, M., Akira, S., Shimizu, A. and Bessho, K.
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Journal Title
Oral Diseases
Volume: 19
Issue: 2
Pages: 144-150
DOI
Related Report
Peer Reviewed
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[Journal Article] Bone regeneration of rat calvarial defect by magnesium calcium phosphate gelatin scaffolds with or without bone morphogenetic protein-22013
Author(s)
Hussain, A., Takahashi, K., Sonobe, J., Bamba, M., Tabata, Y and Bessho, K
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Journal Title
J Maxillofac Oral Surg
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Mastication and risk for diabetes in a Japanese population: a cross-sectional study2013
Author(s)
Yamazaki, T., Yamori, M., Asai, K., Nakano-Araki, I., Yamaguchi, A., Takahashi, K., Sekine, A., Matsuda, F., Kosugi, S., Nakayama, T. and Bessho, K
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Journal Title
PLoS ONE
Volume: (in press)
NAID
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Peer Reviewed
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[Journal Article] Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: A cohort study2012
Author(s)
Yamazaki, T., Yamori, M., Ishizaki, T., Asai, K., Goto, K., Takahashi, K., Nakayama, T. and Bessho, K
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Journal Title
Int J Oral Maxillofac Surg
Volume: 41
Issue: 11
Pages: 1397-1403
DOI
Related Report
Peer Reviewed
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[Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012
Author(s)
Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
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Journal Title
Scientific Reports
Volume: 2
Issue: 1
Pages: 930-930
DOI
Related Report
Peer Reviewed
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[Journal Article] Repeated surgical reduction for fibrous dysplasia of the mandible over a nineteen- year course: a case report2010
Author(s)
Sakata, T., Takahashi, K., Kang, J., Kiso, H., Irie, K., Tsukamoto, H., Nakashima, Y. and Bessho, K
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Journal Title
Asian J Oral Maxillofac Surg
Volume: 22
Pages: 33-36
Related Report
Peer Reviewed
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[Presentation] The relationship between oral health and risk factors of hypertension ; Comparison with Australian Aboriginnals, Sri-lankan and Japanese2012
Author(s)
Asai, K., Yamori, M., Yamazaki, T., Hamada, A., Taguchi, T., Mori, M., Takahashi, K., Sekine, A., Kosugi, S., Matsuda, F., Nakayama, T., Jayattisa, R., Yamori, Y. and Bessho, K
Organizer
ISH2012
Place of Presentation
Sydney
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[Book] Feasibility of gene therapy for tooth regeneration by stimulation of a third dentition: Gene Therapy-Tools and Potential Applications2013
Author(s)
Takahashi, K., Kiso, H., Saito, K., Togo, Y., Tsukamoto, H., Huang, B. and Bessho, K
Publisher
In Tech, Rijeka, Croatia
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