Ionic channel mechanisms in oscillatory cellular bursting underlying respiratory rhythm
| Project/Area Number |
22592214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMANISHI Tadashi 大阪大学, 歯学研究科(研究院), 招へい教員 (20397780)
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| Co-Investigator(Kenkyū-buntansha) |
MIYA Shigenori 大阪大学, 歯学研究科(研究院), 助教 (00397762)
TANIGUCHI Yoshitaka 大阪大学, 歯学研究科(研究院), 招へい教員 (10551468)
IHSIBASHI Miki 大阪大学, 歯学研究科(研究院), 招へい教員 (40412051)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔外科学一般 / 呼吸リズム形成 / ペースメーカ細胞 / 持続性Na電流 / ダイナミッククランプ / 非活性化からの回復 / 持続性Naチャンネル / イオンチャンネルキネティクスモデル / 呼吸中枢細胞 / 抵抗性Na電流 |
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| Research Abstract |
The brainstem pre-Botzinger complex (pre-BotC), the essential excitatory circuit for respiratory rhythm generation, contains a subset of neurons that exhibit intrinsic rhythmic bursting. The burst initiation is considered to rely on the persistent Na+current (INaP), but cellular mechanisms that regulate burst frequency and duration are unknown. Using whole-cell patch-clamp, computational modeling, and dynamic-clamp, we provide evidence that INaP regulates all the essential features of rhythmic burst generation. The results show how the kinetic properties of INaPorchestrate neuronal oscillatory bursting.
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Report
(4 results)
Research Products
(9 results)
