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Development of the very functional biomaterial that possess theability of the control of the drug delivery system.

Research Project

Project/Area Number 22592216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

NINOMIYA Yoshiaki  広島大学, 病院, 助教 (60335685)

Co-Investigator(Kenkyū-buntansha) TAKECHI Masaaki  広島大学, 医歯薬保健学研究院, 准教授 (00304535)
NAKAGAWA Takayuki  広島大学, 病院, 病院助教 (30456230)
KAMATA Nobuyuki  広島大学, 医歯薬保健学研究院, 教授 (70242211)
TADA Misato  広島大学, 病院, 助教 (40572326)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords顎骨骨髄炎 / 高機能性薬物徐放担体 / 高機能性薬物徐法担体 / 抗菌薬 / 骨芽細胞 / 破骨細胞 / 骨伝導性 / 組織学的評価 / 骨形成マーカー遺伝子 / 無機材料 / 有機材料 / 複合材料 / 顎骨骨隨炎
Research Abstract

lf a superior bone filling material were to be developed that allowed high concentrations of antibiotics that acted only locally, and allowed bone formation at the same time, an ideal method of treating osteomyelitis would become available. We created an implant composed of poly(L-lactic acid)(PLLA)and poly(DL-lactic-co-glycolic acid)(PLGA),gentamicin, and α-TCP or β-TCP. The results of sustained-release testing in vivo and in vitro demonstrated the release of effective antibiotic concentrations over 5-month period. Further, when an experimental model of osteomyelitis was produced in rabbits and the implant was inserted after bone marrow curettage, the implant proved effective in preventing the progression of osteomyelitis and in achieving local bone formation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] A case of SAPHO syndrome with diffuse sclerosing osteomyelitis of the mandible treated successfully with prednisolone and bisphosphonate2012

    • Author(s)
      Hatano, H., Shigeishi, H., Higashikawa, K., Shimasue, H., Nishi, H., Oiwa, H., Shindo, H., Takechi, M., Ohge, H. and Kamata, N
    • Journal Title

      J Oral Maxillofac Surg.

      Volume: 70 Pages: 626-631

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering2012

    • Author(s)
      Takechi, M., Ohta, K., Ninomiya, Y., Tada, M., Minami, M., Takamoto, M., Ohta, A., Nakagawa, T., Fukui, A.,Miyamoto, Y, and Kamata, N
    • Journal Title

      Dental Materials Journal

      Volume: 31(3) Pages: 465-471

    • NAID

      10030315479

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of novel interconnected porous hydroxyapatite ceramics (IP-CHA) in a maxillary sinus floor augmentation procedure.2012

    • Author(s)
      Shigeishi,H.,Takechi,M..,Nishimura, M., Takamoto ,M., Minami, M., Ohta, K., and Kamata, N.
    • Journal Title

      Dental Materials Journal

      Volume: 31(1) Pages: 54-60

    • NAID

      10030128207

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering.2012

    • Author(s)
      Takechi,M
    • Journal Title

      Dental Material Journal

      Volume: 31 Pages: 465-471

    • NAID

      10030315479

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口蓋隆起除去骨を応用しISODを行った1症例2011

    • Author(s)
      二宮嘉昭, 武知正晃, 太田耕司,小野重弘,奥井 岳,高本 愛,安部倉 仁,赤川安正,鎌田伸之
    • Journal Title

      広島大学歯学雑誌

      Volume: 43(1) Pages: 61-65

    • NAID

      40018966678

    • Related Report
      2012 Final Research Report
  • [Journal Article] 連通多孔体ハイドロキシアパタイトとチタンメッシュを用いた垂直的骨造成の1例2011

    • Author(s)
      二宮嘉昭,武知正晃,太田耕司,小野重弘, 奥井 岳,太田 彰,高本 愛,鎌田伸之
    • Journal Title

      日本顎顔面インプラント学会 誌

      Volume: 10(1) Pages: 23-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口蓋隆起除去骨を応用しISODを行った1症例2011

    • Author(s)
      二宮嘉昭
    • Journal Title

      広島大学歯学雑誌

      Volume: 第43巻 Pages: 61-65

    • NAID

      40018966678

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 連通多孔体ハイドロキシアパタイトとチタンメッシュを用いた垂直的骨造成の1例2011

    • Author(s)
      二宮嘉昭
    • Journal Title

      日本顎顔面インプラント学会誌

      Volume: 第10巻 Pages: 23-29

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] GM含有α-TCP/ACの顎骨骨髄炎への応用に関する基礎的研究-基本物性と生体親和性について-2010

    • Author(s)
      二宮嘉昭・武知正晃・太田耕司・南 正彦・多田美里 。太田 彰・湯浅哲也・石川邦夫・鎌田伸之
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report
  • [Presentation] GM含有α-TCP/ACの顎骨骨随炎への応用に関する基礎的研究-基本物性と徐放特性について-2010

    • Author(s)
      二宮嘉昭
    • Organizer
      第32回日本バイオマテリアル学会
    • Place of Presentation
      グランドプリンスホテル広島
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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