Investigation of factors involved in the acquisition of pathogenicity of oral Candida species and their control by anti-microbial peptides
| Project/Area Number |
22592217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
OSAKI Tokio 高知大学, その他部局等, 名誉教授 (70031995)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIHARA Kazumasa 鹿児島大学, 医歯(薬)学総合研究科, 教授 (00117516)
YAMAMOTO Tetsuya 高知大学, 教育研究部医療学系, 教授 (00200824)
KAMIKAWA Yoshiaki 鹿児島大学, 歯学部, 診療講師 (30332901)
SATAKE Hidetaka 高知大学, 教育研究部医療学系, 助教 (10304685)
MORISHITA Keiko 高知大学, 医学部附属病院, 医員 (10527584)
KITAMURA Naoya 高知大学, 教育研究部医療学系, 助教 (70351921)
OHNO Seiji 高知大学, 教育研究部医療学系, 助教 (40624995)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔カンジダ症 / 病原因子 / 唾液 / 抗菌ペプチド / カンジダ / 病原性 / 口腔カンジダ菌 / 抗真菌剤 / Phenotype / Genotype / MIC |
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| Research Abstract |
To establish a novel strategy for the control of oral candidiasis, we examined factors involved in the acquisition of pathogenicity of oral Candida species.We revealed that the acquisition of oral Candida albicans is induced by the decrease of salivary anti-microbial peptides such as lactoferrin and histatin 5. This result suggests that anti-microbial peptides are useful for prevention and treatment of oral candidiasis.
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Report
(4 results)
Research Products
(6 results)
