Approach to the elucidation of bone regeneration mechanism -the effect of hyperbaric oxygen environment on bone metabolism

• Project/Area Number: 22592218
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: SASAKI Masanori 九州大学, 大学病院, 助教 (30346803)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Fumi 九州大学, 医学(系)研究院(研究科), 講師 (50274436) ; KAJIOKA Shunichi 九州大学, 医学(系)研究院(研究科), 特任准教授 (90274472)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 高気圧酸素負荷 / 骨再生

Research Abstract

In this study, we analyzed for the various effects of hyperbaric oxygen environment affected the bone regeneration at the cellular level and animal models. At the cellular level, it suggested that hyperbaric air environment and high concentration oxygen environment were affected the different effects on the proliferation and differentiation of osteoclasts. In animal models, it was shown the conflicting effects that high concentration oxygen environment promotes new bone formation in initial period of bone regeneration, and hyperbaric air environment inhibits new bone formation. While reflecting the effects of both environments, it suggested that hyperbaric oxygen environment affects intricately to the bone regeneration.