| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To investigate the pharmacological effects of steroid and bisphosphonate on bone, we tried to establish proliferative epithelial cells and fat-derived mesenchymal stem cells. In this study, we established epithelial cells and CD105-positive mesenchymal stem cells which can differentiate into osteoblasts. Next, we investigated the effects of statin on osteoclastogenesis in RAW 264.7 cells. In this study, it was suggested that atorvastatin and simvastatin may stimulate osteoclastogenesis indirectly by inducing the RANK expression via increasing the expression of TNF-α through MAPK pathways in RAW 264.7 cells.
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