Clinical analysis of Odontogenic tumors and Development of genetherapy using RNAi and anti-sense methods.

Research Project

Project/Area Number	22592220
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Kyushu University
Principal Investigator	NINOMIYA Tomohiro 九州大学, 歯学研究院, 助教 (10346801)
Co-Investigator(Kenkyū-buntansha)	KUBOTA Yasutaka 九州大学, 大学病院, 講師 (60205151)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	歯原性腫瘍 / アンチセンス / 角化嚢胞性歯原性腫瘍 / RNAi / 遺伝子治療 / CaSR / COX-2 / PGE_2
Research Abstract	It is strongly suggested that interleukin-1α(IL-1α) and keratinocyte growth factor(KGF) may play an essential role in regulating the odontogenic tumor growth within the jaw. The volume of marsupialised keratocystic odontogenic tumors was reduced by half over a 239 day cycle. For the new therapy of odontogenic tumors, we are testing the effect of anti-sense methods.

Report

(4 results)