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Clinical analysis of Odontogenic tumors and Development of genetherapy using RNAi and anti-sense methods.

Research Project

Project/Area Number 22592220
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

NINOMIYA Tomohiro  九州大学, 歯学研究院, 助教 (10346801)

Co-Investigator(Kenkyū-buntansha) KUBOTA Yasutaka  九州大学, 大学病院, 講師 (60205151)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯原性腫瘍 / アンチセンス / 角化嚢胞性歯原性腫瘍 / RNAi / 遺伝子治療 / CaSR / COX-2 / PGE_2
Research Abstract

It is strongly suggested that interleukin-1α(IL-1α) and keratinocyte growth factor(KGF) may play an essential role in regulating the odontogenic tumor growth within the jaw. The volume of marsupialised keratocystic odontogenic tumors was reduced by half over a 239 day cycle. For the new therapy of odontogenic tumors, we are testing the effect of anti-sense methods.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2012 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Marsupialisation for keratocystic odontogenic tumours in the mandible: longitudinal image analysis of tumour size using 3D visualised CT scans2012

    • Author(s)
      Shudou H, Sasaki M, Yamashiro T, Tsunomachi S, Takenoshita Y, Kubota Y, Ninomiya T, Kawazu T, Mori Y
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery

      Volume: 41(3) Pages: 290-296

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] CT を用いた三次元構築画像による角化嚢胞性歯原性腫瘍開窓効果の法則性について2010

    • Author(s)
      首藤肇、佐々木匡理、山城崇裕、角町鎮男、杉友貴、恒吉隆奥、窪田泰孝、竹之下康治、吉浦一紀、今城育美、二宮史浩
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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