Clinical analysis of Odontogenic tumors and Development of genetherapy using RNAi and anti-sense methods.
| Project/Area Number |
22592220
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yasutaka 九州大学, 大学病院, 講師 (60205151)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 歯原性腫瘍 / アンチセンス / 角化嚢胞性歯原性腫瘍 / RNAi / 遺伝子治療 / CaSR / COX-2 / PGE_2 |
|---|
| Research Abstract |
It is strongly suggested that interleukin-1α(IL-1α) and keratinocyte growth factor(KGF) may play an essential role in regulating the odontogenic tumor growth within the jaw. The volume of marsupialised keratocystic odontogenic tumors was reduced by half over a 239 day cycle. For the new therapy of odontogenic tumors, we are testing the effect of anti-sense methods.
|
Report
(4 results)
Research Products
(2 results)
