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A study on analysis of oral microbiota of oral cancer patients and application to management perisurgical period

Research Project

Project/Area Number 22592221
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

OOBU Kazunari  九州大学, 大学病院, 講師 (80243955)

Co-Investigator(Kenkyū-buntansha) KAWANO Shintaro  九州大学, 大学病院, 講師 (00398067)
TAKESHITA Toru  九州大学, 歯学研究科(研究院), 准教授 (50546471)
NAKAMURA Seiji  九州大学, 歯学研究科(研究院), 教授 (60189040)
Co-Investigator(Renkei-kenkyūsha) YAMASHITA Yoshihisa  九州大学, 歯学研究科(研究院), 教授 (20192403)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords口腔がん / 口腔細菌叢 / 唾液 / T-RFLP法 / 放射線治療 / 化学放射線療法 / 口腔粘膜炎 / 口腔癌 / 臨床歯学 / 術前放射線化学療法
Research Abstract

The purpose of this study is to find oral microbiota peculiar to oral cancer patient and to investigate whether oral microbiota changes according to the cancer treatment by using the patient's saliva.
An amount of oral microbiota was highest before starting cancer treatment, and lowest during chemoradiotherapy. Though the proportion of Neisseria species and Rothia species became higher under the chemoradiotherapy analyzed by using T-RFLP method, those increase of proportions were not significant statistically analyzed by using Ion PGM method.
These findings suggest that the influence of chemoradiotherapy and surgery on microbiota was not significant, and changes of oral microbiota differ from patient to patient.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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