Study of calcium-sensing receptor in keratocystic odontogenic tumors and development of new therapy

• Project/Area Number: 22592222
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: KURAHARA Shinichi 九州大学, 歯学研究院, 助教 (20304818)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Yasutaka 九州大学, 大学病院, 講師 (60205151) ; KAJIOKA Shunichi 九州大学, 医学研究院, 准教授 (90274472)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: カルシウム感受性受容体 / 角化嚢胞性歯原性腫瘍 / 線維芽細胞 / BMP-2 / 情報伝達機構

Research Abstract

We studied calcium-sensing receptor in the fibroblasts isolated from keratocystic odontogenic tumors. In this study, it was shown that extracellular calcium activated calcium-sensing receptor and induced the expression of BMP-2 mRNA in the fibroblasts isolated from keratocystic odontogenic tumors

Research Products

• [Journal Article] Marsupialization for keratocystic odontogenic tumours in the mandible : longitudinal image analysis of tumour size using 3D visualized CT scans (2012)
  • Author(s): Shudou H, et al
  • Journal Title: Int J Oral Maxillofac Surg Volume: 41 Pages: 290-296
  • Peer Reviewed
• [Journal Article] Imaging findings of neurogenic tumours in the head and neck region (2012)
  • Author(s): Kami YN, et al
  • Journal Title: Dentomaxillofac Radiol Volume: 41 Pages: 18-23
  • Peer Reviewed
• [Journal Article] Multiple schwannomas in the oral floor : case report (2011)
  • Author(s): Kubota Y., et al
  • Journal Title: Br J Oral Maxillofac Surg Volume: 49
  • NAID: 120005133095
  • Peer Reviewed
• [Journal Article] Imaging findings of neurogenic tumors in the head and neck region.
  • Author(s): Kami YN, Chikui T, Okamura K, Kubota Y, Oobu K, Yabuuchi H, Nakayama E, Hashimoto K, Yoshiura K.
  • Journal Title: Dentomaxillofac Radiol. Volume: (accepted)
  • Peer Reviewed
• [Journal Article] Multiple schwannomas in the oral floor: A case report
  • Author(s): Kubota Y, Yanai Y, Kumamaru W, Mori Y.
  • Journal Title: Br J Oral Maxillofac Surg Volume: (accepted)
  • NAID: 120005133095
  • Peer Reviewed
• [Presentation] 角化嚢胞性歯原性腫瘍由来線維芽細胞におけるCaSRを介したBMP-2発現の検討 (2011)
  • Author(s): 矢原佳枝, 他
  • Organizer: 第56回日本口腔外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-21